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    AK8 adenylate kinase 8 [ Homo sapiens (human) ]

    Gene ID: 158067, updated on 9-Jul-2021

    Summary

    Official Symbol
    AK8provided by HGNC
    Official Full Name
    adenylate kinase 8provided by HGNC
    Primary source
    HGNC:HGNC:26526
    See related
    Ensembl:ENSG00000165695 MIM:615365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AK 8; DDX31; C9orf98
    Expression
    Biased expression in testis (RPKM 3.3), thyroid (RPKM 0.7) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AK8 in Genome Data Viewer
    Location:
    9q34.13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (132725574..132879046, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135600965..135754433, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene BarH like homeobox 1 Neighboring gene DEAD-box helicase 31 Neighboring gene general transcription factor IIIC subunit 4 Neighboring gene Sharpr-MPRA regulatory region 7884 Neighboring gene sperm acrosome associated 9 Neighboring gene TSC complex subunit 1 Neighboring gene microRNA 548aw Neighboring gene growth factor independent 1B transcriptional repressor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    GeneReviews: Not available
    Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
    GeneReviews: Not available
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ32704, FLJ36014

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables AMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables adenylate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytidylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytidylate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleoside diphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in 9+2 motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in sperm flagellum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adenylate kinase 8
    Names
    ATP-AMP transphosphorylase 8
    putative adenylate kinase-like protein C9orf98
    NP_001304887.1
    NP_001304888.1
    NP_001358700.1
    NP_001358701.1
    NP_001358702.1
    NP_001358703.1
    NP_689785.1
    XP_005272226.1
    XP_006717028.1
    XP_011516579.1
    XP_011516580.1
    XP_016869797.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317958.2NP_001304887.1  adenylate kinase 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL160165, AL445645
      UniProtKB/Swiss-Prot
      Q96MA6
      Conserved Domains (1) summary
      cd01428
      Location:66258
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    2. NM_001317959.2NP_001304888.1  adenylate kinase 8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL160165, AL445645
      UniProtKB/Swiss-Prot
      Q96MA6
      Related
      ENST00000477396.5
      Conserved Domains (2) summary
      cd01428
      Location:98290
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:98296
      adk; adenylate kinase
    3. NM_001371771.1NP_001358700.1  adenylate kinase 8 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL160165, AL445645
      Conserved Domains (1) summary
      cd01428
      Location:241433
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    4. NM_001371772.1NP_001358701.1  adenylate kinase 8 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL160165, AL445645
      Conserved Domains (2) summary
      PLN02842
      Location:58205
      PLN02842; nucleotide kinase
      cd01428
      Location:225417
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    5. NM_001371773.1NP_001358702.1  adenylate kinase 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL160165, AL445645
      Conserved Domains (1) summary
      cd01428
      Location:66258
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    6. NM_001371774.1NP_001358703.1  adenylate kinase 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL160165, AL445645
      Conserved Domains (1) summary
      cd01428
      Location:66258
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    7. NM_152572.3NP_689785.1  adenylate kinase 8 isoform 1

      See identical proteins and their annotated locations for NP_689785.1

      Status: VALIDATED

      Source sequence(s)
      AL160165, AL445645
      Consensus CDS
      CCDS6954.1
      UniProtKB/Swiss-Prot
      Q96MA6
      Related
      ENSP00000298545.3, ENST00000298545.4
      Conserved Domains (1) summary
      cd01428
      Location:270462
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      132725574..132879046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272169.2XP_005272226.1  adenylate kinase 8 isoform X1

      Conserved Domains (2) summary
      cd01428
      Location:282474
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:282480
      adk; adenylate kinase
    2. XM_011518278.2XP_011516580.1  adenylate kinase 8 isoform X3

      Conserved Domains (2) summary
      cd01428
      Location:196388
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:196394
      adk; adenylate kinase
    3. XM_006716965.2XP_006717028.1  adenylate kinase 8 isoform X2

      Conserved Domains (2) summary
      cd01428
      Location:198390
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:198396
      adk; adenylate kinase
    4. XM_017014308.1XP_016869797.1  adenylate kinase 8 isoform X5

      Conserved Domains (2) summary
      cd01428
      Location:98290
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:98296
      adk; adenylate kinase
    5. XM_011518277.2XP_011516579.1  adenylate kinase 8 isoform X4

      Conserved Domains (3) summary
      cd01428
      Location:71261
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:71270
      adk; adenylate kinase
      cl17190
      Location:282335
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RNA

    1. XR_929719.2 RNA Sequence

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