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    ZNF746 zinc finger protein 746 [ Homo sapiens (human) ]

    Gene ID: 155061, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF746provided by HGNC
    Official Full Name
    zinc finger protein 746provided by HGNC
    Primary source
    HGNC:HGNC:21948
    See related
    Ensembl:ENSG00000181220 MIM:613914; AllianceGenome:HGNC:21948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PARIS
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of neuron death; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 10.6), bone marrow (RPKM 6.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF746 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149472696..149497809, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150654556..150679673, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149169787..149194900, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26814 Neighboring gene tRNA-Cys (anticodon GCA) 11-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149118879-149119378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18755 Neighboring gene zinc finger protein 777 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18759 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:149191224-149192423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149193218-149194161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26816 Neighboring gene tRNA-Cys (anticodon GCA) 16-1 Neighboring gene tRNA-Cys (anticodon GCA) 22-1 Neighboring gene zinc finger family member 767, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ31413

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 746
    Names
    parkin-interacting substrate
    parkin-interacting sustrate

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163474.2NP_001156946.1  zinc finger protein 746 isoform 1

      See identical proteins and their annotated locations for NP_001156946.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC004932, AI991498, AK291814, BC068505
      Consensus CDS
      CCDS55180.1
      UniProtKB/Swiss-Prot
      Q6NUN9
      Related
      ENSP00000508891.1, ENST00000685153.1
      Conserved Domains (6) summary
      cd07765
      Location:106135
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:106156
      KRAB; krueppel associated box
      COG5048
      Location:512589
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:513533
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:567589
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:525549
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001363517.2NP_001350446.1  zinc finger protein 746 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC004932, AC073314
      Consensus CDS
      CCDS87562.1
      UniProtKB/TrEMBL
      A0A2R8YDQ5
      Related
      ENSP00000493970.1, ENST00000644635.1
      Conserved Domains (4) summary
      smart00349
      Location:111171
      KRAB; krueppel associated box
      COG5048
      Location:526603
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:527547
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:581603
      zf-C2H2; Zinc finger, C2H2 type
    3. NM_001394198.1NP_001381127.1  zinc finger protein 746 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC004932, AC073314
      Consensus CDS
      CCDS94227.1
      UniProtKB/TrEMBL
      A0A8J9FQ52
      Related
      ENSP00000395007.3, ENST00000458143.7
      Conserved Domains (6) summary
      smart00349
      Location:111171
      KRAB; krueppel associated box
      sd00017
      Location:528548
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:582604
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:2581
      DUF3669; Zinc finger protein
      pfam13465
      Location:569593
      zf-H2C2_2; Zinc-finger double domain
      pfam16622
      Location:522548
      zf-C2H2_11; zinc-finger C2H2-type
    4. NM_152557.5NP_689770.3  zinc finger protein 746 isoform 2

      See identical proteins and their annotated locations for NP_689770.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks one residue near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AC004932, AC073314, AI991498, BC068505, BM512385
      Consensus CDS
      CCDS5897.1
      UniProtKB/Swiss-Prot
      A8K6Z9, Q6NUN9, Q6ZRF9
      Related
      ENSP00000345140.3, ENST00000340622.8
      Conserved Domains (6) summary
      cd07765
      Location:106135
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:106156
      KRAB; krueppel associated box
      COG5048
      Location:511588
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:512532
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:566588
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:524548
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      149472696..149497809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419925.1XP_047275881.1  zinc finger protein 746 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      150654556..150679673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357354.1XP_054213329.1  zinc finger protein 746 isoform X1