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    Hp haptoglobin [ Mus musculus (house mouse) ]

    Gene ID: 15439, updated on 12-Aug-2019

    Summary

    Official Symbol
    Hpprovided by MGI
    Official Full Name
    haptoglobinprovided by MGI
    Primary source
    MGI:MGI:96211
    See related
    Ensembl:ENSMUSG00000031722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HP-1; preHP2
    Summary
    This gene encodes a plasma glycoprotein called haptoglobin that binds free hemoglobin. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta subunits that form a disulfide-linked tetrameric protein that plays an important role in the sequestration and clearance of extracorpuscular hemoglobin. Mice lacking the encoded protein exhibit stunted development of lymphoid organs associated with lower counts of mature T and B cells in the blood and secondary lymphoid compartments. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in liver adult (RPKM 929.2), liver E18 (RPKM 861.9) and 6 other tissues See more
    Orthologs

    Genomic context

    Location:
    8 D3; 8 57.11 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109575128..109579172, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (112099028..112103072, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 38 Neighboring gene thioredoxin-like 4B Neighboring gene predicted gene, 39247 Neighboring gene dihydroorotate dehydrogenase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
     
    hemoglobin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acute inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    liver development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    blood microparticle ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    haptoglobin-hemoglobin complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329965.1NP_001316894.1  haptoglobin isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC125162, BY166781
    2. NM_017370.2NP_059066.1  haptoglobin isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_059066.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AC125162, AK152698, M96827
      Consensus CDS
      CCDS40470.1
      UniProtKB/Swiss-Prot
      Q61646
      UniProtKB/TrEMBL
      Q3UBS3
      Related
      ENSMUSP00000074436.6, ENSMUST00000074898.7
      Conserved Domains (3) summary
      smart00020
      Location:102340
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:103343
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00084
      Location:3386
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p6 C57BL/6J

      Range
      109575128..109579172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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