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    SLC2A12 solute carrier family 2 member 12 [ Homo sapiens (human) ]

    Gene ID: 154091, updated on 15-Jun-2019

    Summary

    Official Symbol
    SLC2A12provided by HGNC
    Official Full Name
    solute carrier family 2 member 12provided by HGNC
    Primary source
    HGNC:HGNC:18067
    See related
    Ensembl:ENSG00000146411 MIM:610372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLUT8; GLUT12
    Summary
    SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in prostate (RPKM 9.5), endometrium (RPKM 4.6) and 18 other tissues See more
    Orthologs

    Genomic context

    See SLC2A12 in Genome Data Viewer
    Location:
    6q23.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (133987581..134052651, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (134308719..134373789, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TCF21 antisense RNA inducing promoter demethylation Neighboring gene long intergenic non-protein coding RNA 1312 Neighboring gene transcription factor 21 Neighboring gene epithelial splicing regulatory protein 1 pseudogene Neighboring gene TATA-box binding protein like 1 Neighboring gene RNA, 7SL, cytoplasmic 408, pseudogene Neighboring gene high mobility group AT-hook 1 pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    glucose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    hexose transmembrane transport TAS
    Traceable Author Statement
    more info
     
    proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 12
    Names
    GLUT-12
    glucose transporter type 12
    solute carrier family 2 (facilitated glucose transporter), member 12

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145176.3NP_660159.1  solute carrier family 2, facilitated glucose transporter member 12

      See identical proteins and their annotated locations for NP_660159.1

      Status: VALIDATED

      Source sequence(s)
      AL035699, AL833602, AY046419, DB253903
      Consensus CDS
      CCDS5169.1
      UniProtKB/Swiss-Prot
      Q8TD20
      Related
      ENSP00000275230.5, ENST00000275230.5
      Conserved Domains (1) summary
      pfam00083
      Location:44561
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      133987581..134052651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010311.2XP_016865800.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X2

    2. XM_006715349.4XP_006715412.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X1

      Conserved Domains (2) summary
      cd06174
      Location:45363
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG0477
      Location:43371
      ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
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