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    RNF145 ring finger protein 145 [ Homo sapiens (human) ]

    Gene ID: 153830, updated on 17-Jun-2019

    Summary

    Official Symbol
    RNF145provided by HGNC
    Official Full Name
    ring finger protein 145provided by HGNC
    Primary source
    HGNC:HGNC:20853
    See related
    Ensembl:ENSG00000145860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in lung (RPKM 33.4), gall bladder (RPKM 23.7) and 24 other tissues See more
    Orthologs

    Genomic context

    See RNF145 in Genome Data Viewer
    Location:
    5q33.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (159157409..159210053, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (158584417..158637061, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene EBF transcription factor 1 Neighboring gene VISTA enhancer hs1123 Neighboring gene uncharacterized LOC107986467 Neighboring gene long intergenic non-protein coding RNA 2202 Neighboring gene uncharacterized LOC107986468 Neighboring gene long intergenic non-protein coding RNA 1932 Neighboring gene ubiquitin like domain containing CTD phosphatase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
    NHGRI GWA Catalog
    New gene functions in megakaryopoiesis and platelet formation.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ31951, FLJ44310, DKFZp686M11215

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    RING finger protein 145
    NP_001186309.1
    NP_001186310.1
    NP_001186311.1
    NP_001186312.1
    NP_653327.1
    XP_016864627.1
    XP_024310151.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199380.1NP_001186309.1  RING finger protein 145 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK308394, AL831829, BC042684
      Consensus CDS
      CCDS56393.1
      UniProtKB/Swiss-Prot
      Q96MT1
      UniProtKB/TrEMBL
      Q8NDT8
      Related
      ENSP00000430955.1, ENST00000518802.5
      Conserved Domains (3) summary
      pfam12678
      Location:564605
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:565605
      zf-RING_2; Ring finger domain
      pfam13705
      Location:38536
      TRC8_N; TRC8 N-terminal domain
    2. NM_001199381.2NP_001186310.1  RING finger protein 145 isoform 3

      See identical proteins and their annotated locations for NP_001186310.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon, as compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK304435, AL697229, AL831829
      Consensus CDS
      CCDS56392.1
      UniProtKB/Swiss-Prot
      Q96MT1
      UniProtKB/TrEMBL
      Q8NDT8
      Related
      ENSP00000430753.2, ENST00000521606.6
      Conserved Domains (3) summary
      pfam12678
      Location:551592
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:552592
      zf-RING_2; Ring finger domain
      pfam13705
      Location:25523
      TRC8_N; TRC8 N-terminal domain
    3. NM_001199382.1NP_001186311.1  RING finger protein 145 isoform 4

      See identical proteins and their annotated locations for NP_001186311.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 1. The resulting isoform (4) lacks a segment in the N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK304228, AL831829, BC042684, DC418555
      Consensus CDS
      CCDS56391.1
      UniProtKB/Swiss-Prot
      Q96MT1
      UniProtKB/TrEMBL
      Q8NDT8
      Related
      ENSP00000429071.1, ENST00000520638.1
      Conserved Domains (3) summary
      pfam12678
      Location:548589
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:549589
      zf-RING_2; Ring finger domain
      pfam13705
      Location:22520
      TRC8_N; TRC8 N-terminal domain
    4. NM_001199383.2NP_001186312.1  RING finger protein 145 isoform 5

      See identical proteins and their annotated locations for NP_001186312.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' exon, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (5) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK292854, AL831829, CK821118
      Consensus CDS
      CCDS56390.1
      UniProtKB/Swiss-Prot
      Q96MT1
      UniProtKB/TrEMBL
      A8K9Y9, Q8NDT8
      Related
      ENSP00000409064.2, ENST00000424310.6
      Conserved Domains (3) summary
      pfam12678
      Location:534575
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:535575
      zf-RING_2; Ring finger domain
      pfam13705
      Location:8506
      TRC8_N; TRC8 N-terminal domain
    5. NM_144726.2NP_653327.1  RING finger protein 145 isoform 2

      See identical proteins and their annotated locations for NP_653327.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK056513, AL831829, BC042684
      Consensus CDS
      CCDS4344.1
      UniProtKB/Swiss-Prot
      Q96MT1
      UniProtKB/TrEMBL
      Q8NDT8
      Related
      ENSP00000274542.2, ENST00000274542.6
      Conserved Domains (3) summary
      pfam12678
      Location:562603
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:563603
      zf-RING_2; Ring finger domain
      pfam13705
      Location:36534
      TRC8_N; TRC8 N-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      159157409..159210053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009138.2XP_016864627.1  RING finger protein 145 isoform X2

      UniProtKB/Swiss-Prot
      Q96MT1
      Conserved Domains (3) summary
      pfam12678
      Location:534575
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:535575
      zf-RING_2; Ring finger domain
      pfam13705
      Location:8506
      TRC8_N; TRC8 N-terminal domain
    2. XM_024454383.1XP_024310151.1  RING finger protein 145 isoform X1

      Conserved Domains (3) summary
      pfam13705
      Location:24522
      TRC8_N; TRC8 N-terminal domain
      cd16684
      Location:549591
      RING-H2_RNF145; RING finger, H2 subclass, found in RING finger protein 145 (RNF145) and similar proteins
      cl26329
      Location:536641
      zf-rbx1; RING-H2 zinc finger domain
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