Format

Send to:

Choose Destination
    • Showing Current items.

    ROPN1B rhophilin associated tail protein 1B [ Homo sapiens (human) ]

    Gene ID: 152015, updated on 17-Jun-2019

    Summary

    Official Symbol
    ROPN1Bprovided by HGNC
    Official Full Name
    rhophilin associated tail protein 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:31927
    See related
    Ensembl:ENSG00000114547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Restricted expression toward testis (RPKM 113.4) See more
    Orthologs

    Genomic context

    See ROPN1B in Genome Data Viewer
    Location:
    3q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (125969161..125983454)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (125687987..125702297)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 86, member A pseudogene Neighboring gene ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like Neighboring gene fibrosin like 1 pseudogene Neighboring gene solute carrier family 41 member 3 Neighboring gene uncharacterized LOC105374085 Neighboring gene uncharacterized LOC112267887

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    receptor signaling complex scaffold activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    acrosome reaction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cilium organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoskeleton-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    flagellated sperm motility TAS
    Traceable Author Statement
    more info
    PubMed 
    fusion of sperm to egg plasma membrane involved in single fertilization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sperm capacitation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spermatogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ropporin-1B
    Names
    AKAP-binding sperm protein ropporin
    rhophilin-associated protein 1B
    ropporin, rhophilin associated protein 1B
    testis tissue sperm-binding protein Li 83P

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012337.3NP_001012337.1  ropporin-1B

      See identical proteins and their annotated locations for NP_001012337.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF231410, HY006578
      Consensus CDS
      CCDS33841.1
      UniProtKB/Swiss-Prot
      Q9BZX4
      UniProtKB/TrEMBL
      A0A140VKG6
      Related
      ENSP00000251776.4, ENST00000251776.8
      Conserved Domains (1) summary
      cl02594
      Location:1244
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
    2. NM_001308313.2NP_001295242.1  ropporin-1B

      See identical proteins and their annotated locations for NP_001295242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC141849, DC397187
      Consensus CDS
      CCDS33841.1
      UniProtKB/Swiss-Prot
      Q9BZX4
      UniProtKB/TrEMBL
      A0A140VKG6
      Related
      ENSP00000426271.1, ENST00000514116.6
      Conserved Domains (1) summary
      cl02594
      Location:1244
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      125969161..125983454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713513.3XP_006713576.1  ropporin-1B isoform X1

      See identical proteins and their annotated locations for XP_006713576.1

      UniProtKB/Swiss-Prot
      Q9BZX4
      UniProtKB/TrEMBL
      A0A140VKG6
      Conserved Domains (1) summary
      cl02594
      Location:1244
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
    2. XM_005247138.3XP_005247195.1  ropporin-1B isoform X2

      See identical proteins and their annotated locations for XP_005247195.1

      UniProtKB/Swiss-Prot
      Q9BZX4
      Related
      ENSP00000421662.1, ENST00000505382.5
    Support Center