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    H2-Ab1 histocompatibility 2, class II antigen A, beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 14961, updated on 10-Oct-2024

    Summary

    Official Symbol
    H2-Ab1provided by MGI
    Official Full Name
    histocompatibility 2, class II antigen A, beta 1provided by MGI
    Primary source
    MGI:MGI:103070
    See related
    Ensembl:ENSMUSG00000073421 AllianceGenome:MGI:103070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IAb; Ia2; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; I-Abeta
    Summary
    Enables several functions, including peptide antigen binding activity; protein antigen binding activity; and toxic substance binding activity. Involved in several processes, including B cell affinity maturation; cellular response to interferon-gamma; and positive regulation of T-helper 1 type immune response. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and immune response. Located in Golgi apparatus; endosome; and external side of plasma membrane. Is integral component of membrane. Part of MHC class II protein complex. Is expressed in lung; metanephros; and thymus primordium. Orthologous to human HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 2279.6), large intestine adult (RPKM 1316.2) and 12 other tissues See more
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    Genomic context

    See H2-Ab1 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34482201..34488392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34263227..34269418)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4209 Neighboring gene STARR-positive B cell enhancer ABC_E4210 Neighboring gene histocompatibility 2, O region beta locus Neighboring gene STARR-positive B cell enhancer ABC_E7524 Neighboring gene predicted gene 20506 Neighboring gene STARR-positive B cell enhancer ABC_E768 Neighboring gene STARR-positive B cell enhancer ABC_E1193 Neighboring gene STARR-positive B cell enhancer ABC_E8669 Neighboring gene STARR-positive B cell enhancer ABC_E1194 Neighboring gene histocompatibility 2, class II antigen A, alpha Neighboring gene STARR-positive B cell enhancer ABC_E2485 Neighboring gene STARR-positive B cell enhancer ABC_E397 Neighboring gene STARR-positive B cell enhancer ABC_E1505 Neighboring gene STARR-positive B cell enhancer ABC_E1940 Neighboring gene STARR-positive B cell enhancer ABC_E957 Neighboring gene STARR-seq mESC enhancer starr_42428 Neighboring gene histocompatibility 2, class II antigen E beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide antigen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of MHC class II protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histocompatibility 2, class II antigen A, beta 1
    Names
    H-2 class II histocompatibility antigen, A beta chain
    MHC class II H2-IA-beta-psi
    histocompatibility 2, class II antigen A, beta, promoter 1
    major histocompatibility complex class II beta chain
    response to metastatic cancers 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207105.3NP_996988.2  histocompatibility 2, class II antigen A, beta 1 precursor

      See identical proteins and their annotated locations for NP_996988.2

      Status: VALIDATED

      Source sequence(s)
      AK077436, BB056841, BY205244, CK330363
      Consensus CDS
      CCDS37583.1
      UniProtKB/Swiss-Prot
      P14483
      UniProtKB/TrEMBL
      Q3TD53, Q8BPA0
      Related
      ENSMUSP00000041008.6, ENSMUST00000040828.7
      Conserved Domains (2) summary
      cd05766
      Location:125218
      IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
      pfam00969
      Location:40111
      MHC_II_beta; Class II histocompatibility antigen, beta domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34482201..34488392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)