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    METTL11B methyltransferase like 11B [ Homo sapiens (human) ]

    Gene ID: 149281, updated on 17-Jun-2019

    Summary

    Official Symbol
    METTL11Bprovided by HGNC
    Official Full Name
    methyltransferase like 11Bprovided by HGNC
    Primary source
    HGNC:HGNC:31932
    See related
    Ensembl:ENSG00000203740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NTM1B; HOMT1B; C1orf184
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See METTL11B in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (170146047..170168841)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (170115188..170136923)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kinesin associated protein 3 Neighboring gene uncharacterized LOC105371608 Neighboring gene sialic acid binding Ig like lectin 30, pseudogene Neighboring gene microRNA 3119-1 Neighboring gene microRNA 3119-2 Neighboring gene long intergenic non-protein coding RNA 1681 Neighboring gene iron-sulfur cluster assembly enzyme pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1142

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
    NHGRI GWA Catalog

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N-terminal protein N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    N-terminal protein amino acid methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    alpha N-terminal protein methyltransferase 1B
    Names
    X-Pro-Lys N-terminal protein methyltransferase 1B
    methyltransferase-like protein 11B
    NP_001129579.1
    XP_011507534.1
    XP_011507535.1
    XP_011507536.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136107.1NP_001129579.1  alpha N-terminal protein methyltransferase 1B

      See identical proteins and their annotated locations for NP_001129579.1

      Status: VALIDATED

      Source sequence(s)
      BC157860
      Consensus CDS
      CCDS44275.1
      UniProtKB/Swiss-Prot
      Q5VVY1
      Related
      ENSP00000408058.2, ENST00000439373.2
      Conserved Domains (1) summary
      cl17173
      Location:67277
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      170146047..170168841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509232.2XP_011507534.1  alpha N-terminal protein methyltransferase 1B isoform X1

      See identical proteins and their annotated locations for XP_011507534.1

      Conserved Domains (1) summary
      cl17173
      Location:2212
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_011509233.2XP_011507535.1  alpha N-terminal protein methyltransferase 1B isoform X1

      See identical proteins and their annotated locations for XP_011507535.1

      Conserved Domains (1) summary
      cl17173
      Location:2212
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_011509234.2XP_011507536.1  alpha N-terminal protein methyltransferase 1B isoform X1

      See identical proteins and their annotated locations for XP_011507536.1

      Conserved Domains (1) summary
      cl17173
      Location:2212
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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