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    DCDC2B doublecortin domain containing 2B [ Homo sapiens (human) ]

    Gene ID: 149069, updated on 17-Sep-2024

    Summary

    Official Symbol
    DCDC2Bprovided by HGNC
    Official Full Name
    doublecortin domain containing 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:32576
    See related
    Ensembl:ENSG00000222046 AllianceGenome:HGNC:32576
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Sep 2010]
    Expression
    Broad expression in testis (RPKM 2.4), lung (RPKM 2.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DCDC2B in Genome Data Viewer
    Location:
    1p35.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32209089..32216192)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32066991..32074095)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32674690..32681793)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene taxilin alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32664855-32665413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32665414-32665971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 672 Neighboring gene coiled-coil domain containing 28B Neighboring gene H3K4me1 hESC enhancers GRCh37_chr1:32666522-32667041 and GRCh37_chr1:32667042-32667562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32670259-32670760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 675 Neighboring gene IQ motif containing C Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:32681346-32682545 Neighboring gene transmembrane protein 234 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:32687227-32688426 Neighboring gene eukaryotic translation initiation factor 3 subunit I Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:32698370-32698870 Neighboring gene myotubularin related protein 9 like, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 678 Neighboring gene family with sequence similarity 167 member B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    doublecortin domain-containing protein 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099434.2NP_001092904.1  doublecortin domain-containing protein 2B

      See identical proteins and their annotated locations for NP_001092904.1

      Status: REVIEWED

      Source sequence(s)
      AL049795, BC128073, BM980133
      Consensus CDS
      CCDS44100.1
      UniProtKB/Swiss-Prot
      A2VCK2, B7ZBC6
      Related
      ENSP00000386870.1, ENST00000409358.2
      Conserved Domains (2) summary
      cd01617
      Location:987
      DCX; Ubiquitin-like domain of DCX
      cl25424
      Location:131211
      TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      32209089..32216192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      32066991..32074095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)