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    ANKRD35 ankyrin repeat domain 35 [ Homo sapiens (human) ]

    Gene ID: 148741, updated on 17-Jun-2019

    Summary

    Official Symbol
    ANKRD35provided by HGNC
    Official Full Name
    ankyrin repeat domain 35provided by HGNC
    Primary source
    HGNC:HGNC:26323
    See related
    Ensembl:ENSG00000198483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in skin (RPKM 27.5), esophagus (RPKM 8.5) and 5 other tissues See more
    Orthologs

    Genomic context

    See ANKRD35 in Genome Data Viewer
    Location:
    1q21.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (145866560..145885866, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145549209..145568526)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 17 Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene microRNA 6736 Neighboring gene uncharacterized LOC107985593 Neighboring gene integrin subunit alpha 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The interaction of HIV-1 CA with human cellular ankyrin repeat domain 35 protein (ANKRD35) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: PIAS3

    Homology

    Clone Names

    • FLJ25124, MGC126667, MGC126669

    General protein information

    Preferred Names
    ankyrin repeat domain-containing protein 35

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001280799.1NP_001267728.1  ankyrin repeat domain-containing protein 35 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC243547, AK294308, DA399526, HY327286
      Consensus CDS
      CCDS72868.1
      UniProtKB/TrEMBL
      B4DFX6, F6XZD3
      Related
      ENSP00000442671.2, ENST00000544626.2
      Conserved Domains (4) summary
      cd00204
      Location:24136
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:34126
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:841
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:2960
      ANK; ANK repeat [structural motif]
    2. NM_144698.5NP_653299.4  ankyrin repeat domain-containing protein 35 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC243547, AK294308, BC101618, DA399526, HY327286
      Consensus CDS
      CCDS72867.1
      UniProtKB/Swiss-Prot
      Q8N283
      UniProtKB/TrEMBL
      B4DFX6
      Related
      ENSP00000347802.4, ENST00000355594.9
      Conserved Domains (6) summary
      COG1340
      Location:676968
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00204
      Location:81206
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05278
      Location:803950
      PEARLI-4; Arabidopsis phospholipase-like protein (PEARLI 4)
      pfam12796
      Location:58150
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:2474
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:5384
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      145866560..145885866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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