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    ZNF417 zinc finger protein 417 [ Homo sapiens (human) ]

    Gene ID: 147687, updated on 8-Dec-2022

    Summary

    Official Symbol
    ZNF417provided by HGNC
    Official Full Name
    zinc finger protein 417provided by HGNC
    Primary source
    HGNC:HGNC:20646
    See related
    Ensembl:ENSG00000173480 AllianceGenome:HGNC:20646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.9), prostate (RPKM 3.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF417 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57905774..57916592, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61002695..61013513, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58417142..58427960, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 C pseudogene 5 Neighboring gene zinc finger protein 814 Neighboring gene zinc finger protein 418 Neighboring gene zinc finger protein 256

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC34079

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297734.2NP_001284663.1  zinc finger protein 417 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by one amino acid, compared to isoform 1.
      Source sequence(s)
      AC010326
      Consensus CDS
      CCDS74469.1
      UniProtKB/TrEMBL
      M0R230
      Related
      ENSP00000472272.1, ENST00000595559.1
      Conserved Domains (5) summary
      smart00349
      Location:1469
      KRAB; krueppel associated box
      COG5048
      Location:272567
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:353373
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1453
      KRAB; KRAB box
      pfam13465
      Location:393418
      zf-H2C2_2; Zinc-finger double domain
    2. NM_152475.3NP_689688.2  zinc finger protein 417 isoform 1

      See identical proteins and their annotated locations for NP_689688.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC010326, BC025783, BP358797
      Consensus CDS
      CCDS12965.1
      UniProtKB/Swiss-Prot
      B4DEU1, Q8TAU3
      Related
      ENSP00000311319.4, ENST00000312026.6
      Conserved Domains (5) summary
      smart00349
      Location:1570
      KRAB; krueppel associated box
      COG5048
      Location:273568
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:354374
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1554
      KRAB; KRAB box
      pfam13465
      Location:394419
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57905774..57916592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526473.4XP_011524775.1  zinc finger protein 417 isoform X2

      Conserved Domains (6) summary
      smart00349
      Location:83138
      KRAB; krueppel associated box
      COG5048
      Location:341636
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:422442
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:364386
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:83122
      KRAB; KRAB box
      pfam13465
      Location:462487
      zf-H2C2_2; Zinc-finger double domain
    2. XM_047438222.1XP_047294178.1  zinc finger protein 417 isoform X1

    3. XM_047438223.1XP_047294179.1  zinc finger protein 417 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61002695..61013513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)