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    Gnrhr gonadotropin releasing hormone receptor [ Mus musculus (house mouse) ]

    Gene ID: 14715, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Gnrhrprovided by MGI
    Official Full Name
    gonadotropin releasing hormone receptorprovided by MGI
    Primary source
    MGI:MGI:95790
    See related
    Ensembl:ENSMUSG00000029255 AllianceGenome:MGI:95790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable gonadotropin-releasing hormone receptor activity; growth hormone-releasing hormone receptor activity; and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of cell population proliferation. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adenohypophysis; jaw; mandibular process; and ovary. Used to study hypogonadotropic hypogonadism 7 with or without anosmia. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to human GNRHR (gonadotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 E1; 5 43.56 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (86328613..86345760, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (86180754..86197901, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2747 Neighboring gene predicted gene, 24524 Neighboring gene signal transducing adaptor family member 1 Neighboring gene ubiquitin-like modifier activating enzyme 6 Neighboring gene STARR-seq mESC enhancer starr_13544 Neighboring gene STARR-positive B cell enhancer ABC_E10326 Neighboring gene transmembrane protease, serine 11c Neighboring gene STARR-seq mESC enhancer starr_13545 Neighboring gene predicted gene, 25473 Neighboring gene transmembrane protease, serine 11d Neighboring gene STARR-seq mESC enhancer starr_13546 Neighboring gene STARR-seq mESC enhancer starr_13547 Neighboring gene predicted gene, 35367 Neighboring gene STARR-seq mESC enhancer starr_13548

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling. Wang X, et al. Immunol Invest, 2022 Jul. PMID 34132158
    2. Gonadotropin-releasing hormone receptor (Gnrhr) gene knock out: Normal growth and development of sensory, motor and spatial orientation behavior but altered metabolism in neonatal and prepubertal mice. Busby ER, et al. PLoS One, 2017. PMID 28346489, Free PMC Article
    3. Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation. Mayevu NM, et al. Mol Cell Endocrinol, 2015 Feb 15. PMID 25583361
    4. Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy. Janovick JA, et al. Proc Natl Acad Sci U S A, 2013 Dec 24. PMID 24324164, Free PMC Article
    5. Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary. Torrealday S, et al. Endocrinology, 2013 Oct. PMID 23913446, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional GnRH receptor signaling regulates striatal cholinergic neurons in neonatal but not in adult mice.
      Title: Functional GnRH receptor signaling regulates striatal cholinergic neurons in neonatal but not in adult mice.
    2. AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling.
      Title: AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling.
    3. Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling.
      Title: Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling.
    4. Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes.
      Title: Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes.
    5. Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor.
      Title: Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor.
    6. GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors.
      Title: GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors.
    7. GnRH receptorexpression levels depend on JUN and are critical for reproductive function.
      Title: GnRH Receptor Expression and Reproductive Function Depend on JUN in GnRH Receptor‒Expressing Cells.
    8. leptin's direct stimulatory actions on gonadotrope GnRHR correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. There also is a direct MSI1 interaction with 3'-UTR of Gnrhr mRNA.
      Title: Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression.
    9. the age-dependent basal and regulated Gnrhr transcription could account for the initial blockade and subsequent activation of the reproductive system during development.
      Title: The relationship between basal and regulated Gnrhr expression in rodent pituitary gonadotrophs.
    10. GnRH-GnRHR system is not essential for growth or motor/sensory/orientation behavior during the first month of life prior to puberty onset. The lack of the GnRH-GnRHR axis, however, did affect females resulting in reduced subcutaneous inguinal fat pad weight and increased glucose with possible insulin resistance.
      Title: Gonadotropin-releasing hormone receptor (Gnrhr) gene knock out: Normal growth and development of sensory, motor and spatial orientation behavior but altered metabolism in neonatal and prepubertal mice.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (6)  1 citation
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables gonadotropin-releasing hormone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth hormone-releasing hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gonadotropin-releasing hormone receptor
    Names
    gnRH receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310651.1 → NP_001297580.1  gonadotropin-releasing hormone receptor isoform 2

      See identical proteins and their annotated locations for NP_001297580.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC107634
      Consensus CDS
      CCDS80313.1
      UniProtKB/TrEMBL
      A0A192B0U8, D3Z6P7
      Related
      ENSMUSP00000108999.2, ENSMUST00000113372.2
      Conserved Domains (1) summary
      pfam00001
      Location:76 → 174
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_001310653.1 → NP_001297582.1  gonadotropin-releasing hormone receptor isoform 3

      See identical proteins and their annotated locations for NP_001297582.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks the 3' exon and its transcription extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (3) has a distinct, shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AC107634
      Consensus CDS
      CCDS84897.1
      UniProtKB/TrEMBL
      Q6P8H4
      Related
      ENSMUSP00000092238.3, ENSMUST00000094654.3
      Conserved Domains (1) summary
      pfam00001
      Location:76 → 247
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_010323.2 → NP_034453.1  gonadotropin-releasing hormone receptor isoform 1

      See identical proteins and their annotated locations for NP_034453.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC107634, L01119
      Consensus CDS
      CCDS19379.1
      UniProtKB/Swiss-Prot
      Q01776, Q61611
      Related
      ENSMUSP00000031172.9, ENSMUST00000031172.9
      Conserved Domains (1) summary
      pfam00001
      Location:76 → 322
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      86328613..86345760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320667.1 → XP_017176156.1  gonadotropin-releasing hormone receptor isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:37 → 68
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:36 → 174
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01776.1 GenPept UniProtKB/Swiss-Prot:Q01776

    Gene LinkOut

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