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    SLC47A2 solute carrier family 47 member 2 [ Homo sapiens (human) ]

    Gene ID: 146802, updated on 26-Jun-2019

    Summary

    Official Symbol
    SLC47A2provided by HGNC
    Official Full Name
    solute carrier family 47 member 2provided by HGNC
    Primary source
    HGNC:HGNC:26439
    See related
    Ensembl:ENSG00000180638 MIM:609833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MATE2; MATE2K; MATE2-B; MATE2-K
    Summary
    This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward kidney (RPKM 17.1) See more
    Orthologs

    Genomic context

    See SLC47A2 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (19678292..19719598, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19581626..19622990, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MT-CO1 pseudogene 39 Neighboring gene aldehyde dehydrogenase 3 family member A2 Neighboring gene aldehyde dehydrogenase 3 family member A1 Neighboring gene TBC1 domain family member 25 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Homology

    Clone Names

    • FLJ31196

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    drug transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    multidrug and toxin extrusion protein 2
    Names
    kidney-specific H(+)/organic cation antiporter
    solute carrier family 47 (multidrug and toxin extrusion), member 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052805.1 RefSeqGene

      Range
      7250..45665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001099646.2NP_001093116.1  multidrug and toxin extrusion protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001093116.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2, also known as MATE2-K), compared to isoform 1.
      Source sequence(s)
      AB250364, AC005722
      UniProtKB/Swiss-Prot
      Q86VL8
      Conserved Domains (2) summary
      COG0534
      Location:33467
      NorM; Na+-driven multidrug efflux pump [Defense mechanisms]
      cd13132
      Location:30464
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    2. NM_001256663.2NP_001243592.1  multidrug and toxin extrusion protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001243592.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site and contains an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AB250364, AC005722, BC035288, DA312379
      Consensus CDS
      CCDS58530.1
      UniProtKB/Swiss-Prot
      Q86VL8
      Related
      ENSP00000338084.6, ENST00000350657.9
      Conserved Domains (2) summary
      COG0534
      Location:33481
      NorM; Na+-driven multidrug efflux pump [Defense mechanisms]
      cd13132
      Location:30478
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    3. NM_152908.4NP_690872.2  multidrug and toxin extrusion protein 2 isoform 1

      See identical proteins and their annotated locations for NP_690872.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1), also known as MATE2.
      Source sequence(s)
      AC005722, BC050578
      Consensus CDS
      CCDS11211.1
      UniProtKB/Swiss-Prot
      Q86VL8
      Related
      ENSP00000326671.5, ENST00000325411.9
      Conserved Domains (2) summary
      COG0534
      Location:33503
      NorM; Na+-driven multidrug efflux pump [Defense mechanisms]
      cd13132
      Location:30500
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    RNA

    1. NR_135624.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AB250364, BC035288, BX648861
      Related
      ENST00000463318.5
    2. NR_135625.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AB250701, AC005722, AK307647, BC035288
      Related
      ENST00000574239.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      19678292..19719598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024221.1XP_016879710.1  multidrug and toxin extrusion protein 2 isoform X1

    2. XM_017024222.2XP_016879711.1  multidrug and toxin extrusion protein 2 isoform X2

    3. XM_017024223.1XP_016879712.1  multidrug and toxin extrusion protein 2 isoform X3

    4. XM_017024224.1XP_016879713.1  multidrug and toxin extrusion protein 2 isoform X4

      Related
      ENSP00000391848.2, ENST00000433844.2
    5. XM_017024226.1XP_016879715.1  multidrug and toxin extrusion protein 2 isoform X6

    6. XM_017024225.1XP_016879714.1  multidrug and toxin extrusion protein 2 isoform X5

    RNA

    1. XR_001752432.1 RNA Sequence

    2. XR_001752433.1 RNA Sequence

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