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    CSNK1E casein kinase 1 epsilon [ Homo sapiens (human) ]

    Gene ID: 1454, updated on 17-Jun-2024

    Summary

    Official Symbol
    CSNK1Eprovided by HGNC
    Official Full Name
    casein kinase 1 epsilonprovided by HGNC
    Primary source
    HGNC:HGNC:2453
    See related
    Ensembl:ENSG00000213923 MIM:600863; AllianceGenome:HGNC:2453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKIe; HCKIE; CKIepsilon
    Summary
    The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
    Expression
    Ubiquitous expression in brain (RPKM 32.2), endometrium (RPKM 32.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CSNK1E in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38290691..38318084, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38754994..38782389, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38686697..38714089, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38620666-38621166 Neighboring gene transmembrane protein 184B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38624990-38625720 Neighboring gene TMEM184B antisense RNA 1 Neighboring gene small nucleolar RNA, H/ACA box 92 Neighboring gene RNA, 7SL, cytoplasmic 704, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38659892-38660392 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:38667767-38668476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38679509-38680035 Neighboring gene TPTEP2-CSNK1E readthrough Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38685261-38685970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38685971-38686678 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:38694325-38695524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38706687-38707466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38714878-38715782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38718279-38719070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38720450-38720962 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:38720963-38721473 Neighboring gene Sharpr-MPRA regulatory region 8587 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38723521-38724032 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38737560-38737744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38740513-38741012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38743105-38744002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13716 Neighboring gene TPTE pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38793649-38794432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38799517-38800018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38800019-38800518 Neighboring gene uncharacterized LOC105373030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38813561-38814060

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough TPTEP2-CSNK1E

    Readthrough gene: TPTEP2-CSNK1E, Included gene: TPTEP2

    Clone Names

    • MGC10398

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of amyloid-beta formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of non-canonical Wnt signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    casein kinase I isoform epsilon
    NP_001885.1
    NP_689407.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016707.2 RefSeqGene

      Range
      5651..32393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001894.5NP_001885.1  casein kinase I isoform epsilon

      See identical proteins and their annotated locations for NP_001885.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB024597, BC013088, BU517079
      UniProtKB/Swiss-Prot
      P49674
      UniProtKB/TrEMBL
      Q53EZ1, Q5U045
      Related
      ENSP00000352929.3, ENST00000359867.7
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    2. NM_152221.3NP_689407.1  casein kinase I isoform epsilon

      See identical proteins and their annotated locations for NP_689407.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer and predominant transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL020993, BC006490, BC013088, BQ642398, BU517079, CF594072
      UniProtKB/Swiss-Prot
      P49674
      UniProtKB/TrEMBL
      Q53EZ1, Q5U045
      Related
      ENSP00000380044.1, ENST00000396832.6
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      38290691..38318084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      38754994..38782389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)