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    TMEM86A transmembrane protein 86A [ Homo sapiens (human) ]

    Gene ID: 144110, updated on 23-Nov-2023

    Summary

    Official Symbol
    TMEM86Aprovided by HGNC
    Official Full Name
    transmembrane protein 86Aprovided by HGNC
    Primary source
    HGNC:HGNC:26890
    See related
    Ensembl:ENSG00000151117 AllianceGenome:HGNC:26890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable alkenylglycerophosphocholine hydrolase activity and alkenylglycerophosphoethanolamine hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney (RPKM 12.8), skin (RPKM 8.6) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TMEM86A in Genome Data Viewer
    Location:
    11p15.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18698779..18704785)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18796841..18802847)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18720326..18726332)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4507 Neighboring gene uncharacterized LOC105376578 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:18670593-18671313 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:18671314-18672033 Neighboring gene MPRA-validated peak1228 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18690003-18690504 Neighboring gene SRSF3 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:18720033-18720534 Neighboring gene IGSF22 antisense RNA 1 Neighboring gene immunoglobulin superfamily member 22 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4511 Neighboring gene protein tyrosine phosphatase non-receptor type 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:18770656-18771538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18783056-18783556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18783557-18784057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18792057-18792558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18792559-18793058 Neighboring gene Sharpr-MPRA regulatory region 5421 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:18819993-18821192 Neighboring gene MAS related GPR family member X8, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90119

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alkenylglycerophosphocholine hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    lysoplasmalogenase TMEM86A
    Names
    lysoplasmalogenase-like protein TMEM86A
    NP_699178.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153347.3NP_699178.1  lysoplasmalogenase TMEM86A

      See identical proteins and their annotated locations for NP_699178.1

      Status: VALIDATED

      Source sequence(s)
      AC103974
      Consensus CDS
      CCDS7844.1
      UniProtKB/Swiss-Prot
      Q8N2M4, Q96AJ0
      Related
      ENSP00000280734.2, ENST00000280734.3
      Conserved Domains (1) summary
      pfam07947
      Location:37224
      YhhN; YhhN-like protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      18698779..18704785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      18796841..18802847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)