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    DYDC1 DPY30 domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 143241, updated on 3-Apr-2024

    Summary

    Official Symbol
    DYDC1provided by HGNC
    Official Full Name
    DPY30 domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:23460
    See related
    Ensembl:ENSG00000170788 MIM:615154; AllianceGenome:HGNC:23460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPY30D1
    Summary
    This gene encodes a member of a family of proteins that contains a DPY30 domain. The encoded protein is involved in acrosome formation during spermatid development. This gene locus overlaps with a closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
    Expression
    Restricted expression toward testis (RPKM 10.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DYDC1 in Genome Data Viewer
    Location:
    10q23.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (80336013..80356755, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (81205115..81225857, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (82095858..82116511, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:82032694-82033893 Neighboring gene Sharpr-MPRA regulatory region 13640 Neighboring gene methionine adenosyltransferase 1A Neighboring gene zinc finger protein 519 pseudogene 1 Neighboring gene MPRA-validated peak1026 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr10:82123032-82123216 Neighboring gene DPY30 domain containing 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:82163430-82163602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2545 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82168661-82169254 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:82170101-82170600 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:82177040-82177582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3654 Neighboring gene peroxiredoxin like 2A Neighboring gene Sharpr-MPRA regulatory region 12974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3655 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82214375-82214892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3659 Neighboring gene Sharpr-MPRA regulatory region 907 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82224527-82225098 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82225099-82225670 Neighboring gene Sharpr-MPRA regulatory region 4556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3660 Neighboring gene tetraspanin 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2547 Neighboring gene Sharpr-MPRA regulatory region 2609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82257110-82258073 Neighboring gene Sharpr-MPRA regulatory region 10623

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ43920

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    part_of radial spoke ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    DPY30 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001269053.2NP_001255982.1  DPY30 domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_001255982.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-4 all encode the longer isoform (a).
      Source sequence(s)
      AL359195, BC019250, BI828082
      Consensus CDS
      CCDS7366.1
      UniProtKB/Swiss-Prot
      A8K927, Q5QP03, Q5QP04, Q6WNP4, Q6ZU87, Q8WWB3
      UniProtKB/TrEMBL
      X1WI33
      Related
      ENSP00000361276.1, ENST00000372202.6
      Conserved Domains (2) summary
      pfam04625
      Location:18117
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam05186
      Location:142
      Dpy-30; Dpy-30 motif
    2. NM_001370155.1NP_001357084.1  DPY30 domain-containing protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1-4 all encode the longer isoform (a).
      Source sequence(s)
      AL359195
      Consensus CDS
      CCDS7366.1
      UniProtKB/Swiss-Prot
      A8K927, Q5QP03, Q5QP04, Q6WNP4, Q6ZU87, Q8WWB3
      UniProtKB/TrEMBL
      X1WI33
      Conserved Domains (2) summary
      pfam04625
      Location:18117
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam05186
      Location:142
      Dpy-30; Dpy-30 motif
    3. NM_001370156.1NP_001357085.1  DPY30 domain-containing protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-4 all encode the longer isoform (a).
      Source sequence(s)
      AL359195, DB091778
      Consensus CDS
      CCDS7366.1
      UniProtKB/Swiss-Prot
      A8K927, Q5QP03, Q5QP04, Q6WNP4, Q6ZU87, Q8WWB3
      UniProtKB/TrEMBL
      X1WI33
      Conserved Domains (2) summary
      pfam04625
      Location:18117
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam05186
      Location:142
      Dpy-30; Dpy-30 motif
    4. NM_001370157.1NP_001357086.1  DPY30 domain-containing protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL359195
      UniProtKB/TrEMBL
      X1WI33
      Conserved Domains (2) summary
      pfam04625
      Location:18117
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam05186
      Location:142
      Dpy-30; Dpy-30 motif
    5. NM_138812.4NP_620167.1  DPY30 domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_620167.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-4 all encode the longer isoform (a).
      Source sequence(s)
      AL359195, BC019250
      Consensus CDS
      CCDS7366.1
      UniProtKB/Swiss-Prot
      A8K927, Q5QP03, Q5QP04, Q6WNP4, Q6ZU87, Q8WWB3
      UniProtKB/TrEMBL
      X1WI33
      Related
      ENSP00000361278.3, ENST00000372204.7
      Conserved Domains (2) summary
      pfam04625
      Location:18117
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam05186
      Location:142
      Dpy-30; Dpy-30 motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      80336013..80356755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015749.2XP_016871238.1  DPY30 domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      X1WI33
    2. XM_011539335.2XP_011537637.1  DPY30 domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011537637.1

      UniProtKB/Swiss-Prot
      A8K927, Q5QP03, Q5QP04, Q6WNP4, Q6ZU87, Q8WWB3
      UniProtKB/TrEMBL
      X1WI33
      Conserved Domains (2) summary
      pfam04625
      Location:18117
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam05186
      Location:142
      Dpy-30; Dpy-30 motif
    3. XM_047424655.1XP_047280611.1  DPY30 domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K927, Q5QP03, Q5QP04, Q6WNP4, Q6ZU87, Q8WWB3
    4. XM_005269549.5XP_005269606.1  DPY30 domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005269606.1

      UniProtKB/TrEMBL
      X1WI33
      Conserved Domains (1) summary
      pfam05186
      Location:142
      Dpy-30; Dpy-30 motif
    5. XM_005269550.5XP_005269607.1  DPY30 domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005269607.1

      UniProtKB/TrEMBL
      X1WI33
      Related
      ENSP00000414798.1, ENST00000454362.5
      Conserved Domains (1) summary
      pfam05186
      Location:142
      Dpy-30; Dpy-30 motif
    6. XM_011539334.3XP_011537636.1  DPY30 domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011537636.1

      UniProtKB/TrEMBL
      X1WI33
      Conserved Domains (1) summary
      pfam05186
      Location:142
      Dpy-30; Dpy-30 motif

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      81205115..81225857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364906.1XP_054220881.1  DPY30 domain-containing protein 1 isoform X3

    2. XM_054364904.1XP_054220879.1  DPY30 domain-containing protein 1 isoform X1

    3. XM_054364902.1XP_054220877.1  DPY30 domain-containing protein 1 isoform X1

    4. XM_054364905.1XP_054220880.1  DPY30 domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K927, Q5QP03, Q5QP04, Q6WNP4, Q6ZU87, Q8WWB3
    5. XM_054364903.1XP_054220878.1  DPY30 domain-containing protein 1 isoform X1

    6. XM_054364907.1XP_054220882.1  DPY30 domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K927, Q5QP03, Q5QP04, Q6WNP4, Q6ZU87, Q8WWB3