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    ITLN2 intelectin 2 [ Homo sapiens (human) ]

    Gene ID: 142683, updated on 15-Apr-2019

    Summary

    Official Symbol
    ITLN2provided by HGNC
    Official Full Name
    intelectin 2provided by HGNC
    Primary source
    HGNC:HGNC:20599
    See related
    Ensembl:ENSG00000158764 MIM:609874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HL2; HL-2
    Expression
    Biased expression in small intestine (RPKM 141.3), duodenum (RPKM 79.7) and 1 other tissue See more
    Orthologs

    Genomic context

    See ITLN2 in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (160945020..160957378, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (160914810..160924589, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene intelectin 1 Neighboring gene spermine synthase pseudogene Neighboring gene uncharacterized LOC101928372 Neighboring gene F11 receptor Neighboring gene thiosulfate sulfurtransferase like domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    intelectin-2
    Names
    endothelial lectin HL-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080878.3NP_543154.1  intelectin-2 precursor

      See identical proteins and their annotated locations for NP_543154.1

      Status: VALIDATED

      Source sequence(s)
      AL354714, AL591806, AY358905
      Consensus CDS
      CCDS1212.1
      UniProtKB/Swiss-Prot
      Q8WWU7
      Related
      ENSP00000357008.3, ENST00000368029.4
      Conserved Domains (1) summary
      cl00085
      Location:4994
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      160945020..160957378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509210.1XP_011507512.1  intelectin-2 isoform X1

      See identical proteins and their annotated locations for XP_011507512.1

      UniProtKB/Swiss-Prot
      Q8WWU7
      Conserved Domains (1) summary
      cl00085
      Location:4994
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    2. XM_024453321.1XP_024309089.1  intelectin-2 isoform X2

      Conserved Domains (1) summary
      cl00085
      Location:4893
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
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