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    DCANP1 dendritic cell associated nuclear protein [ Homo sapiens (human) ]

    Gene ID: 140947, updated on 17-Jun-2019

    Summary

    Official Symbol
    DCANP1provided by HGNC
    Official Full Name
    dendritic cell associated nuclear proteinprovided by HGNC
    Primary source
    HGNC:HGNC:24459
    See related
    Ensembl:ENSG00000251380 MIM:609710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCNP1; C5orf20
    Summary
    This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008]
    Orthologs

    Genomic context

    See DCANP1 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (135444214..135447348, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134779904..134783038, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 66 Neighboring gene H2A histone family member Y Neighboring gene VISTA enhancer hs1473 Neighboring gene TIFA inhibitor Neighboring gene neurogenin 1 Neighboring gene solute carrier family 25 member 48 Neighboring gene C-X-C motif chemokine ligand 14

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: TIFAB

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    auditory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cochlea development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cochlea morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    craniofacial suture morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    genitalia development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    genitalia morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hard palate morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    learned vocalization behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mastication IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of relaxation of muscle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of saliva secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peristalsis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of muscle organ development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    thorax and anterior abdomen determination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    trigeminal nerve development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vestibulocochlear nerve formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dendritic cell nuclear protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130848.3NP_570900.1  dendritic cell nuclear protein 1

      See identical proteins and their annotated locations for NP_570900.1

      Status: REVIEWED

      Source sequence(s)
      AC022092
      Consensus CDS
      CCDS4186.1
      UniProtKB/Swiss-Prot
      Q8TF63
      Related
      ENSP00000421871.1, ENST00000503143.3

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      135444214..135447348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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