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    DYNLL2 dynein light chain LC8-type 2 [ Homo sapiens (human) ]

    Gene ID: 140735, updated on 5-Mar-2024

    Summary

    Official Symbol
    DYNLL2provided by HGNC
    Official Full Name
    dynein light chain LC8-type 2provided by HGNC
    Primary source
    HGNC:HGNC:24596
    See related
    Ensembl:ENSG00000264364 MIM:608942; AllianceGenome:HGNC:24596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Dlc2; DNCL1B; RSPH22
    Summary
    Predicted to enable dynein intermediate chain binding activity and dynein light intermediate chain binding activity. Predicted to be involved in cilium assembly. Located in 9+0 non-motile cilium and centrosome. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 120.2), kidney (RPKM 90.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DYNLL2 in Genome Data Viewer
    Location:
    17q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (58083419..58095542)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (58957420..58969544)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (56160780..56172903)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371840 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:56129666-56130865 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56152348-56152941 Neighboring gene DYNLL2 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 5901 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8760 Neighboring gene Sharpr-MPRA regulatory region 5260 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:56219338-56219838 Neighboring gene olfactory receptor family 4 subfamily D member 1 Neighboring gene msh homeobox 2 pseudogene 1 Neighboring gene olfactory receptor family 4 subfamily D member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC17810

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in 9+0 non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary tip TAS
    Traceable Author Statement
    more info
     
    located_in cilium TAS
    Traceable Author Statement
    more info
     
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    part_of myosin V complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    dynein light chain 2, cytoplasmic
    Names
    8 kDa dynein light chain b
    DLC8b
    radial spoke 22 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080677.3NP_542408.1  dynein light chain 2, cytoplasmic

      See identical proteins and their annotated locations for NP_542408.1

      Status: VALIDATED

      Source sequence(s)
      AC015813, BC010744, BF528423, CN280282, DA140058, DB022843
      Consensus CDS
      CCDS11601.1
      UniProtKB/Swiss-Prot
      B2R5B4, Q96FJ2
      Related
      ENSP00000477310.1, ENST00000579991.3
      Conserved Domains (1) summary
      cd21452
      Location:588
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      58083419..58095542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      58957420..58969544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)