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    TRIM69 tripartite motif containing 69 [ Homo sapiens (human) ]

    Gene ID: 140691, updated on 28-Sep-2024

    Summary

    Official Symbol
    TRIM69provided by HGNC
    Official Full Name
    tripartite motif containing 69provided by HGNC
    Primary source
    HGNC:HGNC:17857
    See related
    Ensembl:ENSG00000185880 MIM:616017; AllianceGenome:HGNC:17857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Trif; HSD34; RNF36; HSD-34
    Summary
    This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 19.8) and brain (RPKM 1.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRIM69 in Genome Data Viewer
    Location:
    15q21.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (44736528..44767827)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (42544526..42575817)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (45028726..45060025)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1044 Neighboring gene microRNA 10393 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:45020107-45021094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:45021095-45022080 Neighboring gene beta-2-microglobulin Neighboring gene ring finger protein 4B, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4328 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:45084988-45085176 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:45098626-45098830 Neighboring gene Sharpr-MPRA regulatory region 4183 Neighboring gene sorbitol dehydrogenase 2, pseudogene Neighboring gene uncharacterized LOC105370798 Neighboring gene RNA, U1 small nuclear 119, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: RNF4BP

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM69
    Names
    RFP-like domain-containing protein trimless
    RING-type E3 ubiquitin transferase TRIM69
    ring finger protein 36
    NP_001288073.1
    NP_001288074.1
    NP_001288075.1
    NP_542783.2
    NP_892030.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033935.1 RefSeqGene

      Range
      5167..36466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001301144.2NP_001288073.1  E3 ubiquitin-protein ligase TRIM69 isoform c

      See identical proteins and their annotated locations for NP_001288073.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) lacks an alternate exon and uses an alternate splice site, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant a. The encoded isoform (c, also known as TRIMLESS alpha) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC122108, AF302088, BI827618, DB524904
      Consensus CDS
      CCDS73719.1
      UniProtKB/Swiss-Prot
      Q86WT6
      Related
      ENSP00000453549.1, ENST00000560442.5
      Conserved Domains (1) summary
      cd15818
      Location:107293
      SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
    2. NM_001301145.2NP_001288074.1  E3 ubiquitin-protein ligase TRIM69 isoform d

      See identical proteins and their annotated locations for NP_001288074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) lacks an alternate exon and uses two alternate splice sites, and it thus differs in its 5' UTR, initiates translation at a downstream in-frame start codon, and lacks an in-frame segment in the central coding region, compared to variant a. The encoded isoform (d, also known as TRIMLESS beta) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC122108, AF302089, BI827618, DB524904
      Consensus CDS
      CCDS76746.1
      UniProtKB/Swiss-Prot
      Q86WT6
      Related
      ENSP00000453332.1, ENST00000558329.5
      Conserved Domains (1) summary
      cd15818
      Location:90276
      SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
    3. NM_001301146.2NP_001288075.1  E3 ubiquitin-protein ligase TRIM69 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (e) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant a, resulting in an isoform (e) that is shorter than isoform a.
      Source sequence(s)
      AC122108, AF302088, BI465168, BI827618, DB524904
      Consensus CDS
      CCDS76745.1
      UniProtKB/TrEMBL
      H0YL66
      Related
      ENSP00000453077.1, ENST00000561043.5
      Conserved Domains (1) summary
      cd15818
      Location:74260
      SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
    4. NM_080745.5NP_542783.2  E3 ubiquitin-protein ligase TRIM69 isoform b

      See identical proteins and their annotated locations for NP_542783.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) lacks an alternate in-frame exon in the 5' coding region, compared to variant a, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AC122108, BC033314, BI827618, DB524904
      Consensus CDS
      CCDS10114.1
      UniProtKB/Swiss-Prot
      Q86WT6
      Related
      ENSP00000342922.4, ENST00000338264.8
      Conserved Domains (1) summary
      cd15818
      Location:152338
      SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
    5. NM_182985.5NP_892030.3  E3 ubiquitin-protein ligase TRIM69 isoform a

      See identical proteins and their annotated locations for NP_892030.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC122108, AF302088, AY305385, BI827618, DB524904
      Consensus CDS
      CCDS32220.1
      UniProtKB/Swiss-Prot
      A8MX03, Q309B0, Q4G1A5, Q6W897, Q86WT6, Q8IYY3, Q8WY16, Q8WY17
      UniProtKB/TrEMBL
      A0A0G2JPI4
      Related
      ENSP00000332284.3, ENST00000329464.9
      Conserved Domains (3) summary
      cd15818
      Location:311497
      SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
      cl17238
      Location:4181
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl23765
      Location:168299
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      44736528..44767827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187605.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      59905..91198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      42544526..42575817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)