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    TCP10L t-complex 10 like [ Homo sapiens (human) ]

    Gene ID: 140290, updated on 8-Dec-2022

    Summary

    Official Symbol
    TCP10Lprovided by HGNC
    Official Full Name
    t-complex 10 likeprovided by HGNC
    Primary source
    HGNC:HGNC:11657
    See related
    Ensembl:ENSG00000242220 MIM:608365; AllianceGenome:HGNC:11657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRED77; C21orf77; TCP10A-1; TCP10A-2; LINC00846
    Summary
    Enables several functions, including identical protein binding activity; protein self-association; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 24.4) See more
    Orthologs
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    Genomic context

    See TCP10L in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (32573721..32585523, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (30923998..30951524, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (33946031..33957833, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene eva-1 homolog C Neighboring gene exosome component 3 pseudogene 1 Neighboring gene CFAP298-TCP10L readthrough Neighboring gene RNA, 5S ribosomal pseudogene 490 Neighboring gene cilia and flagella associated protein 298 Neighboring gene olfactory receptor family 7 subfamily E member 23 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough CFAP298-TCP10L

    Readthrough gene: CFAP298-TCP10L, Included gene: CFAP298

    Homology

    Clone Names

    • FLJ10932, MGC34297

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein self-association IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    T-complex protein 10A homolog 1
    Names
    T-complex protein 10A homolog 2
    T-complex protein 10A-1
    T-complex protein 10A-2
    TCP10-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144659.7NP_653260.1  T-complex protein 10A homolog 1

      See identical proteins and their annotated locations for NP_653260.1

      Status: VALIDATED

      Source sequence(s)
      AF115967, AP000274, BC027970, BG721020, HY036551
      Consensus CDS
      CCDS13616.1
      UniProtKB/Swiss-Prot
      Q8TDR4, Q96LN5
      Related
      ENSP00000300258.3, ENST00000300258.8

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      32573721..32585523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      30923998..30951524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018277.1: Suppressed sequence

      Description
      NM_018277.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.