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    Erf Ets2 repressor factor [ Mus musculus (house mouse) ]

    Gene ID: 13875, updated on 28-Oct-2024

    Summary

    Official Symbol
    Erfprovided by MGI
    Official Full Name
    Ets2 repressor factorprovided by MGI
    Primary source
    MGI:MGI:109637
    See related
    Ensembl:ENSMUSG00000040857 AllianceGenome:MGI:109637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within chorio-allantoic fusion; ectodermal cell differentiation; and trophoblast giant cell differentiation. Located in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Human ortholog(s) of this gene implicated in craniosynostosis. Orthologous to human ERF (ETS2 repressor factor). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 38.0), ovary adult (RPKM 27.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Erf in Genome Data Viewer
    Location:
    7 A3; 7 13.73 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24941985..24950522, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25242560..25251104, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene death effector domain-containing DNA binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E868 Neighboring gene STARR-positive B cell enhancer ABC_E1724 Neighboring gene microRNA 7048 Neighboring gene RIKEN cDNA 9130221H12 gene Neighboring gene zinc finger protein 526 Neighboring gene glycogen synthase kinase 3 alpha Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26024418-26024601 Neighboring gene STARR-positive B cell enhancer ABC_E3706 Neighboring gene predicted gene, 53354 Neighboring gene STARR-seq mESC enhancer starr_18298 Neighboring gene STARR-positive B cell enhancer ABC_E348 Neighboring gene STARR-positive B cell enhancer ABC_E24 Neighboring gene predicted gene, 45974 Neighboring gene capicua transcriptional repressor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ETS domain-containing transcription factor ERF
    Names
    Est2 repressor factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412415.1NP_001399344.1  ETS domain-containing transcription factor ERF isoform a

      Status: VALIDATED

      Source sequence(s)
      AC156992
    2. NM_001412417.1NP_001399346.1  ETS domain-containing transcription factor ERF isoform c

      Status: VALIDATED

      Source sequence(s)
      AC156992
    3. NM_001412418.1NP_001399347.1  ETS domain-containing transcription factor ERF isoform c

      Status: VALIDATED

      Source sequence(s)
      AC156992
    4. NM_010155.4NP_034285.3  ETS domain-containing transcription factor ERF isoform b

      See identical proteins and their annotated locations for NP_034285.3

      Status: VALIDATED

      Source sequence(s)
      AC156992
      Consensus CDS
      CCDS20978.1
      UniProtKB/Swiss-Prot
      P70459, Q3TXK4, Q6P544, Q7TSJ1
      UniProtKB/TrEMBL
      A0A0R4J0I0
      Related
      ENSMUSP00000041912.9, ENSMUST00000045847.15
      Conserved Domains (1) summary
      smart00413
      Location:26111
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24941985..24950522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)