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    Elf5 E74-like factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 13711, updated on 2-Oct-2018

    Summary

    Official Symbol
    Elf5provided by MGI
    Official Full Name
    E74-like factor 5provided by MGI
    Primary source
    MGI:MGI:1335079
    See related
    Ensembl:ENSMUSG00000027186 Vega:OTTMUSG00000014860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESE-2; ESE-5; ESE-5.
    Expression
    Biased expression in lung adult (RPKM 8.8), mammary gland adult (RPKM 6.4) and 6 other tissues See more
    Orthologs

    Genomic context

    See Elf5 in Genome Data Viewer
    Location:
    2; 2 E2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (103411693..103450989)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (103252255..103291146)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930006I01 gene Neighboring gene cDNA sequence BC016548 Neighboring gene catalase Neighboring gene RIKEN cDNA 8030431J09 gene Neighboring gene ankyrin repeat and BTB (POZ) domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
      Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    • Prolactin signaling pathway, conserved biosystem (from KEGG)
      Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ectoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ectodermal cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mammary gland epithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ETS-related transcription factor Elf-5
    Names
    Epithelium specific Ets-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145813.1NP_001139285.1  ETS-related transcription factor Elf-5

      See identical proteins and their annotated locations for NP_001139285.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AK132484, AL773505
      Consensus CDS
      CCDS16477.1
      UniProtKB/Swiss-Prot
      Q8VDK3
      UniProtKB/TrEMBL
      Q3V1F7
      Related
      ENSMUSP00000126941.1, ENSMUST00000164172.7
      Conserved Domains (2) summary
      cd08538
      Location:39122
      SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
      smart00413
      Location:162246
      ETS; erythroblast transformation specific domain
    2. NM_010125.3NP_034255.2  ETS-related transcription factor Elf-5

      See identical proteins and their annotated locations for NP_034255.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AF049702, AK132484, AK145214, AL773505
      Consensus CDS
      CCDS16477.1
      UniProtKB/Swiss-Prot
      Q8VDK3
      UniProtKB/TrEMBL
      Q3ULZ4, Q3V1F7
      Related
      ENSMUSP00000028609.7, OTTMUSP00000015784, ENSMUST00000028609.13, OTTMUST00000035295
      Conserved Domains (2) summary
      cd08538
      Location:39122
      SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
      smart00413
      Location:162246
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      103411693..103450989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498704.1XP_006498767.1  ETS-related transcription factor Elf-5 isoform X1

      Conserved Domains (2) summary
      cd08538
      Location:70153
      SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
      smart00413
      Location:193277
      ETS; erythroblast transformation specific domain
    2. XM_006498705.1XP_006498768.1  ETS-related transcription factor Elf-5 isoform X2

      See identical proteins and their annotated locations for XP_006498768.1

      UniProtKB/Swiss-Prot
      Q8VDK3
      UniProtKB/TrEMBL
      Q3V1F7
      Conserved Domains (2) summary
      cd08538
      Location:39122
      SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
      smart00413
      Location:162246
      ETS; erythroblast transformation specific domain
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