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    S1pr1 sphingosine-1-phosphate receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 13609, updated on 9-Jul-2019

    Summary

    Official Symbol
    S1pr1provided by MGI
    Official Full Name
    sphingosine-1-phosphate receptor 1provided by MGI
    Primary source
    MGI:MGI:1096355
    See related
    Ensembl:ENSMUSG00000045092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S1p; Edg1; Lpb1; S1p1; AI849002
    Summary
    This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]
    Expression
    Broad expression in lung adult (RPKM 117.9), spleen adult (RPKM 77.3) and 21 other tissues See more
    Orthologs

    Genomic context

    See S1pr1 in Genome Data Viewer
    Location:
    3; 3 G1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (115710433..115715055, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (115413351..115417973, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene crumbs homolog 1 pseudogene Neighboring gene predicted gene, 40124 Neighboring gene RIKEN cDNA A930005H10 gene Neighboring gene diphthamide biosynthesis 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    sphingolipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    sphingosine-1-phosphate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sphingosine-1-phosphate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    T cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    blood vessel maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle tissue growth involved in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart trabecula morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    sphingosine-1-phosphate receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sphingosine-1-phosphate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sphingosine 1-phosphate receptor 1
    Names
    S1P receptor 1
    S1P receptor Edg-1
    endothelial differentiation G-protein coupled receptor 1
    endothelial differentiation sphingolipid G-protein-coupled receptor 1
    lysophospholipid receptor B1
    sphingosine 1-phosphate receptor Edg-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007901.5NP_031927.2  sphingosine 1-phosphate receptor 1

      See identical proteins and their annotated locations for NP_031927.2

      Status: REVIEWED

      Source sequence(s)
      AC126932, AK004591
      Consensus CDS
      CCDS17781.1
      UniProtKB/Swiss-Prot
      O08530
      Related
      ENSMUSP00000050897.2, ENSMUST00000055676.3
      Conserved Domains (1) summary
      cd15346
      Location:46322
      7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      115710433..115715055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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