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    HUS1B HUS1 checkpoint clamp component B [ Homo sapiens (human) ]

    Gene ID: 135458, updated on 15-Jun-2019

    Summary

    Official Symbol
    HUS1Bprovided by HGNC
    Official Full Name
    HUS1 checkpoint clamp component Bprovided by HGNC
    Primary source
    HGNC:HGNC:16485
    See related
    Ensembl:ENSG00000188996 MIM:609713
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]
    Orthologs

    Genomic context

    See HUS1B in Genome Data Viewer
    Location:
    6p25.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (655939..656964, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (655939..656964, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 4 Neighboring gene uncharacterized LOC105374875 Neighboring gene exocyst complex component 2 Neighboring gene microtubule affinity regulating kinase 2 pseudogene Neighboring gene uncharacterized LOC105374873

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • DNA Damage Response, organism-specific biosystem (from WikiPathways)
      DNA Damage Response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
    • miRNA Regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
      miRNA Regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126746, MGC126748

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intra-S DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    meiotic DNA integrity checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic DNA replication checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    checkpoint clamp complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    checkpoint protein HUS1B
    Names
    HUS1 checkpoint homolog b
    hHUS1B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148959.3NP_683762.2  checkpoint protein HUS1B

      See identical proteins and their annotated locations for NP_683762.2

      Status: REVIEWED

      Source sequence(s)
      AL357054, BC101699
      Consensus CDS
      CCDS4470.1
      UniProtKB/Swiss-Prot
      Q8NHY5
      Related
      ENSP00000370293.2, ENST00000380907.2
      Conserved Domains (1) summary
      pfam04005
      Location:1278
      Hus1; Hus1-like protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      655939..656964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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