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    CORT cortistatin [ Homo sapiens (human) ]

    Gene ID: 1325, updated on 23-Nov-2021

    Summary

    Official Symbol
    CORTprovided by HGNC
    Official Full Name
    cortistatinprovided by HGNC
    Primary source
    HGNC:HGNC:2257
    See related
    Ensembl:ENSG00000241563 MIM:602784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SST2; CST-14; CST-17; CST-29
    Summary
    This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]
    Expression
    Biased expression in brain (RPKM 6.6), testis (RPKM 2.0) and 1 other tissue See more
    Orthologs
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    Genomic context

    See CORT in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (10450031..10451998)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (10510088..10512055)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 15261 Neighboring gene CENPS-CORT readthrough Neighboring gene centromere protein S Neighboring gene DNA fragmentation factor subunit alpha Neighboring gene peroxisomal biogenesis factor 14 Neighboring gene Sharpr-MPRA regulatory region 5895

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough CENPS-CORT

    Readthrough gene: CENPS-CORT, Included gene: CENPS

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of FANCM-MHF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Fanconi anaemia nuclear complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cortistatin
    Names
    cortistatin-14
    cortistatin-17
    cortistatin-29
    prepro-cortistatin
    preprocortistatin
    somatostatin 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302.5NP_001293.3  cortistatin preproprotein

      See identical proteins and their annotated locations for NP_001293.3

      Status: REVIEWED

      Source sequence(s)
      AY358561, BC040034, BC119724, BF590359
      Consensus CDS
      CCDS117.2
      UniProtKB/Swiss-Prot
      O00230
      UniProtKB/TrEMBL
      Q8IUV6
      Related
      ENSP00000366248.4, ENST00000377049.4
      Conserved Domains (1) summary
      pfam03002
      Location:87104
      Somatostatin; Somatostatin/Cortistatin family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      10450031..10451998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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