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    METTL6 methyltransferase like 6 [ Homo sapiens (human) ]

    Gene ID: 131965, updated on 17-Jun-2019

    Summary

    Official Symbol
    METTL6provided by HGNC
    Official Full Name
    methyltransferase like 6provided by HGNC
    Primary source
    HGNC:HGNC:28343
    See related
    Ensembl:ENSG00000206562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in testis (RPKM 1.5), brain (RPKM 1.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See METTL6 in Genome Data Viewer
    Location:
    3p25.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (15381275..15427580, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (15422782..15469054, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SH3 domain binding protein 5 Neighboring gene RNA, U6 small nuclear 454, pseudogene Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 7 Neighboring gene RNA, U6 small nuclear 1024, pseudogene Neighboring gene ELL associated factor 1 Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene microRNA 4270

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC24132

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    tRNA (cytosine-5-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    tRNA C5-cytosine methylation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    methyltransferase-like protein 6
    NP_001288719.1
    NP_001288720.1
    NP_001288721.1
    NP_001317591.1
    NP_689609.2
    XP_005264924.1
    XP_006713033.1
    XP_006713035.1
    XP_011531659.1
    XP_016861207.1
    XP_016861208.1
    XP_016861211.1
    XP_016861212.1
    XP_016861213.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301790.1NP_001288719.1  methyltransferase-like protein 6 isoform 2

      See identical proteins and their annotated locations for NP_001288719.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC027125, AK293370, BG701912, CX872865, Z44406
      Consensus CDS
      CCDS77706.1
      UniProtKB/TrEMBL
      B4DDX3
      Related
      ENSP00000410726.2, ENST00000450816.6
      Conserved Domains (1) summary
      cd02440
      Location:70142
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001301791.1NP_001288720.1  methyltransferase-like protein 6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains multiple coding region differences, including an alternate 3' terminal exon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC027125, BG701912, BU183521, CA430635
      Conserved Domains (2) summary
      COG0500
      Location:57178
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84178
      Methyltransf_12; Methyltransferase domain
    3. NM_001301792.1NP_001288721.1  methyltransferase-like protein 6 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC027125, BC022400, BG701912, BI913767, CX872865, Z44406
      UniProtKB/Swiss-Prot
      Q8TCB7
      Conserved Domains (2) summary
      COG0500
      Location:57177
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84177
      Methyltransf_12; Methyltransferase domain
    4. NM_001330662.2NP_001317591.1  methyltransferase-like protein 6 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate exon in the 3' coding region and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 5, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC027125, BX114702
      Consensus CDS
      CCDS87051.1
      UniProtKB/Swiss-Prot
      Q8TCB7
      Related
      ENSP00000373299.5, ENST00000383789.9
      Conserved Domains (2) summary
      COG0500
      Location:57178
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84178
      Methyltransf_12; Methyltransferase domain
    5. NM_152396.3NP_689609.2  methyltransferase-like protein 6 isoform 1

      See identical proteins and their annotated locations for NP_689609.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC027125, BC022400, BG701912, CX872865, Z44406
      Consensus CDS
      CCDS43056.1
      UniProtKB/Swiss-Prot
      Q8TCB7
      Related
      ENSP00000373300.3, ENST00000383790.7
      Conserved Domains (2) summary
      COG0500
      Location:57215
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84182
      Methyltransf_12; Methyltransferase domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      15381275..15427580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005719.1XP_016861208.1  methyltransferase-like protein 6 isoform X2

      UniProtKB/TrEMBL
      B4DDX3
      Conserved Domains (1) summary
      cd02440
      Location:70142
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_017005723.1XP_016861212.1  methyltransferase-like protein 6 isoform X6

    3. XM_005264867.4XP_005264924.1  methyltransferase-like protein 6 isoform X1

      See identical proteins and their annotated locations for XP_005264924.1

      UniProtKB/Swiss-Prot
      Q8TCB7
      Related
      ENSP00000407613.1, ENST00000443029.5
      Conserved Domains (2) summary
      COG0500
      Location:57215
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84182
      Methyltransf_12; Methyltransferase domain
    4. XM_006712972.4XP_006713035.1  methyltransferase-like protein 6 isoform X3

      Conserved Domains (2) summary
      COG0500
      Location:57178
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84178
      Methyltransf_12; Methyltransferase domain
    5. XM_017005722.2XP_016861211.1  methyltransferase-like protein 6 isoform X5

      Conserved Domains (2) summary
      COG0500
      Location:57177
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84177
      Methyltransf_12; Methyltransferase domain
    6. XM_017005718.2XP_016861207.1  methyltransferase-like protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8TCB7
      Conserved Domains (2) summary
      COG0500
      Location:57215
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84182
      Methyltransf_12; Methyltransferase domain
    7. XM_006712970.4XP_006713033.1  methyltransferase-like protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006713033.1

      UniProtKB/Swiss-Prot
      Q8TCB7
      Conserved Domains (2) summary
      COG0500
      Location:57215
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84182
      Methyltransf_12; Methyltransferase domain
    8. XM_011533357.3XP_011531659.1  methyltransferase-like protein 6 isoform X4

      Conserved Domains (2) summary
      COG0500
      Location:57178
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84178
      Methyltransf_12; Methyltransferase domain
    9. XM_017005724.2XP_016861213.1  methyltransferase-like protein 6 isoform X7

    RNA

    1. XR_001740018.2 RNA Sequence

    2. XR_001740019.2 RNA Sequence

    3. XR_940377.3 RNA Sequence

    4. XR_002959491.1 RNA Sequence

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