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    TAF8 TATA-box binding protein associated factor 8 [ Homo sapiens (human) ]

    Gene ID: 129685, updated on 10-Oct-2024

    Summary

    Official Symbol
    TAF8provided by HGNC
    Official Full Name
    TATA-box binding protein associated factor 8provided by HGNC
    Primary source
    HGNC:HGNC:17300
    See related
    Ensembl:ENSG00000137413 MIM:609514; AllianceGenome:HGNC:17300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    II; TAF; TBN; NEDMLHB; TAFII43; TAFII-43; TAF(II)43
    Summary
    This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.7), lymph node (RPKM 3.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TAF8 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (42050524..42087462)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (41878783..41915706)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42018262..42055200)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:41884515-41885714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41892998-41893498 Neighboring gene mediator complex subunit 20 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41906017-41906832 Neighboring gene bystin like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41906833-41907648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41908777-41909728 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:41928638-41928835 Neighboring gene cyclin D3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:41932711-41933221 Neighboring gene uncharacterized LOC105375059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41976875-41977831 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41977832-41978787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41984389-41984890 Neighboring gene Sharpr-MPRA regulatory regions 12575 and 14060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24534 Neighboring gene RNA, U6 small nuclear 761, pseudogene Neighboring gene skeletal muscle cis-regulatory module in CCND3 intron Neighboring gene ReSE screen-validated silencer GRCh37_chr6:42007359-42007580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42011196-42011696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24537 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:42013050-42013640 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:42013641-42014230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17197 Neighboring gene H3K27ac hESC enhancers GRCh37_chr6:42017885-42018436 and GRCh37_chr6:42018437-42018988 Neighboring gene Sharpr-MPRA regulatory region 7068 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:42067953-42068174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17200 Neighboring gene chromosome 6 open reading frame 132 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42104000-42104697 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42108933-42109612 Neighboring gene GUCA1ANB-GUCA1A readthrough Neighboring gene ciliary microtubule inner protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32821

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IC
    Inferred by Curator
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription factor TFIID complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 8
    Names
    TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa
    TBP-associated factor 43 kDa
    TBP-associated factor 8
    TBP-associated factor TAFII43
    TBP-associated factor, RNA polymerase II, 43 kD
    hTAFII43
    protein taube nuss
    taube nuss homolog
    transcription initiation factor TFIID 43 kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410906.1NP_001397835.1  transcription initiation factor TFIID subunit 8 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL512274, AL513008
      Consensus CDS
      CCDS93918.1
      UniProtKB/TrEMBL
      A0A8I5QL44
      Related
      ENSP00000510786.1, ENST00000686229.1
    2. NM_001410907.1NP_001397836.1  transcription initiation factor TFIID subunit 8 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL512274, AL513008
      Consensus CDS
      CCDS93919.1
      Related
      ENSP00000411900.2, ENST00000456846.6
    3. NM_138572.3NP_612639.2  transcription initiation factor TFIID subunit 8 isoform 1

      See identical proteins and their annotated locations for NP_612639.2

      Status: REVIEWED

      Source sequence(s)
      AF465841, AL512274, BI828714
      Consensus CDS
      CCDS43462.1
      UniProtKB/Swiss-Prot
      Q5T0K1, Q7Z7C8, Q8N4R9, Q96M52
      UniProtKB/TrEMBL
      A0A8I5KVM3
      Related
      ENSP00000362068.3, ENST00000372977.8
      Conserved Domains (2) summary
      cd08049
      Location:144197
      TAF8; TATA Binding Protein (TBP) Associated Factor 8
      pfam07524
      Location:29106
      Bromo_TP; Bromodomain associated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      42050524..42087462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418177.1XP_047274133.1  transcription initiation factor TFIID subunit 8 isoform X2

    2. XM_047418174.1XP_047274130.1  transcription initiation factor TFIID subunit 8 isoform X1

      Related
      ENSP00000362073.4, ENST00000372982.8
    3. XM_047418178.1XP_047274134.1  transcription initiation factor TFIID subunit 8 isoform X4

    4. XM_017010245.2XP_016865734.1  transcription initiation factor TFIID subunit 8 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KXI2
      Related
      ENSP00000510369.1, ENST00000687601.1
    5. XM_017010244.3XP_016865733.1  transcription initiation factor TFIID subunit 8 isoform X3

    6. XM_047418175.1XP_047274131.1  transcription initiation factor TFIID subunit 8 isoform X1

      Related
      ENSP00000417867.1, ENST00000494547.5
    7. XM_005248849.3XP_005248906.1  transcription initiation factor TFIID subunit 8 isoform X6

      UniProtKB/TrEMBL
      A0A0A0MRR3
      Related
      ENSP00000362069.3, ENST00000372978.7
      Conserved Domains (2) summary
      pfam07524
      Location:29106
      Bromo_TP; Bromodomain associated
      pfam10406
      Location:145163
      TAF8_C; Transcription factor TFIID complex subunit 8 C-term

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      41878783..41915706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354207.1XP_054210182.1  transcription initiation factor TFIID subunit 8 isoform X1

    2. XM_054354211.1XP_054210186.1  transcription initiation factor TFIID subunit 8 isoform X4

    3. XM_054354212.1XP_054210187.1  transcription initiation factor TFIID subunit 8 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KXI2
    4. XM_054354210.1XP_054210185.1  transcription initiation factor TFIID subunit 8 isoform X3

    5. XM_054354208.1XP_054210183.1  transcription initiation factor TFIID subunit 8 isoform X1

    6. XM_054354213.1XP_054210188.1  transcription initiation factor TFIID subunit 8 isoform X6

    7. XM_054354209.1XP_054210184.1  transcription initiation factor TFIID subunit 8 isoform X2