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    H3C14 H3 clustered histone 14 [ Homo sapiens (human) ]

    Gene ID: 126961, updated on 7-Apr-2024


    Official Symbol
    H3C14provided by HGNC
    Official Full Name
    H3 clustered histone 14provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000203811 MIM:142780; AllianceGenome:HGNC:20503
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H3; H3.2; H3/M; H3F2; H3FM; H3FN; H3C13; H3C15; HIST2H3C
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]
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    Genomic context

    See H3C14 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149840687..149841208, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (148964837..148965358, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149812259..149812780, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1654 Neighboring gene H3 clustered histone 13 Neighboring gene H4 clustered histone 14 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149812048-149812621 Neighboring gene H2A clustered histone 18 Neighboring gene H2B clustered histone 19, pseudogene

    Genomic regions, transcripts, and products


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Clone Names

    • MGC9629

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    Process Evidence Code Pubs
    involved_in chromatin organization NAS
    Non-traceable Author Statement
    more info
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    part_of nucleosome IPI
    Inferred from Physical Interaction
    more info
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info

    General protein information

    Preferred Names
    histone H3.2
    H3 histone family, member M
    H3 histone, family 2
    H3-clustered histone 13
    H3-clustered histone 15
    histone 2, H3c
    histone H3/m
    histone cluster 2 H3 family member c
    histone cluster 2, H3c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021059.3NP_066403.2  histone H3.2

      See identical proteins and their annotated locations for NP_066403.2

      Status: REVIEWED

      Source sequence(s)
      Consensus CDS
      A2BDF6, A6NFS4, Q6B053, Q71DI3
      A8K4Y7, B2R6Y1
      ENSP00000358154.1, ENST00000369158.2
      Conserved Domains (1) summary
      PTZ00018; histone H3; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly


    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      149840687..149841208 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0


    1. NC_060925.1 Alternate T2T-CHM13v2.0

      148964837..148965358 complement
      GenBank, FASTA, Sequence Viewer (Graphics)