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    Chil1 chitinase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 12654, updated on 19-Aug-2018

    Summary

    Official Symbol
    Chil1provided by MGI
    Official Full Name
    chitinase-like 1provided by MGI
    Primary source
    MGI:MGI:1340899
    See related
    Ensembl:ENSMUSG00000064246 Vega:OTTMUSG00000030091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gp39; Brp39; Chi3l1; AW208766
    Expression
    Restricted expression toward lung adult (RPKM 398.3) See more
    Orthologs

    Genomic context

    See Chil1 in Genome Data Viewer
    Location:
    1 E4; 1 58.15 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (134182170..134190031)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (136078981..136086608)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene chitinase 1 (chitotriosidase) Neighboring gene predicted gene, 46158 Neighboring gene myosin binding protein H Neighboring gene adenosine A1 receptor Neighboring gene predicted gene, 32221

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of NF-kappaB-inducing kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-8 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lung development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    chitinase-3-like protein 1
    Names
    CGP-39
    GP-39
    breast regression protein 39
    cartilage glycoprotein 39
    chitinase 3-like 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007695.3NP_031721.2  chitinase-3-like protein 1 precursor

      See identical proteins and their annotated locations for NP_031721.2

      Status: VALIDATED

      Source sequence(s)
      AI853039, AK051475, CJ147225
      Consensus CDS
      CCDS48368.1
      UniProtKB/Swiss-Prot
      Q61362
      Related
      ENSMUSP00000080717.3, ENSMUST00000082060.9
      Conserved Domains (2) summary
      cd02872
      Location:32388
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:31366
      Glyco_18; Glyco_18 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      134182170..134190031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529111.3XP_006529174.1  chitinase-3-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q61362
      Related
      ENSMUSP00000119205.1, OTTMUSP00000038877, ENSMUST00000156873.7, OTTMUST00000074545
      Conserved Domains (2) summary
      cd02872
      Location:22378
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:21356
      Glyco_18; Glyco_18 domain
    2. XM_006529112.3XP_006529175.1  chitinase-3-like protein 1 isoform X2

      Conserved Domains (2) summary
      smart00636
      Location:1293
      Glyco_18; Glyco_18 domain
      cl10447
      Location:1315
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
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