Chgb chromogranin B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chgbprovided by MGI
Official Full Name: chromogranin Bprovided by MGI
Primary source: MGI:MGI:88395
See related: Ensembl:ENSMUSG00000027350 AllianceGenome:MGI:88395
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cgB; sgI; Scg-1
Summary: Predicted to be located in extracellular region. Predicted to be active in extracellular space and secretory granule. Is expressed in several structures, including adrenal gland; gut; nervous system; reproductive system; and retina. Orthologous to human CHGB (chromogranin B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 97.0), cerebellum adult (RPKM 86.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F2; 2 64.74 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (132623562..132636999)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (132781642..132795079)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study using live-cell imaging at single vesicle resolution revealed a normal number of fusion events upon bursts of action potentials in CgA/B-/- neurons. Data indicate that the two chromogranins are dispensable for cargo sorting in the regulated secretory pathway and dense-core vesicle in mouse hippocampal neurons.
Title: Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.
This analysis of mice lacking Cgs highlights the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood.
Title: Mice lacking chromogranins exhibit increased aggressive and depression-like behaviour.
Chromogranin B contributes to a highly efficient system that directly mediates monoamine accumulation and exocytosis in large dense core secretory vesicles.
Title: The functional role of chromogranins in exocytosis.
Although chromogranins regulate the amine concentration in LDCVs, they are not completely essential.
Title: Chromogranins A and B are key proteins in amine accumulation, but the catecholamine secretory pathway is conserved without them.
C-terminal domain of chromogranin B regulates intracellular calcium signaling.
Title: C-terminal domain of chromogranin B regulates intracellular calcium signaling.
CgB is not required for normal insulin granule biogenesis or maintenance in vivo, but is essential for adequate secretion of islet hormones
Title: Defective secretion of islet hormones in chromogranin-B deficient mice.
Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles in mice.
Title: Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles.
Striatal neuropeptide mechanisms in experimental parkinsonism were elucidated.
Title: Striatal alterations of secretogranin-1, somatostatin, prodynorphin, and cholecystokinin peptides in an experimental mouse model of Parkinson disease.
CGB was localized in the nucleus; transcription control role of CGB in the nucleus
Title: Localization of the secretory granule marker protein chromogranin B in the nucleus. Potential role in transcription control.
CGB may play an important modulatory role in the control of Ca2+ release from the endoplasmic reticulum
Title: A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Chgb (e-PCR), detects polymorphism
- UniSTS:141335

UniSTS:141336 (e-PCR)
- UniSTS:141336

Chgb (e-PCR), detects polymorphism
- UniSTS:141336

X51429 (e-PCR)
- UniSTS:178716

X53028 (e-PCR)
- UniSTS:178718

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: secretogranin-1

Names: secretogranin I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.