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    INO80C INO80 complex subunit C [ Homo sapiens (human) ]

    Gene ID: 125476, updated on 17-Jun-2019

    Summary

    Official Symbol
    INO80Cprovided by HGNC
    Official Full Name
    INO80 complex subunit Cprovided by HGNC
    Primary source
    HGNC:HGNC:26994
    See related
    Ensembl:ENSG00000153391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IES6; hIes6; C18orf37
    Expression
    Broad expression in testis (RPKM 20.7), esophagus (RPKM 7.5) and 24 other tissues See more
    Orthologs

    Genomic context

    See INO80C in Genome Data Viewer
    Location:
    18q12.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (35468333..35497960, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (33032194..33078110, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372063 Neighboring gene GATA motif-containing MPRA enhancer 294 Neighboring gene microRNA 3975 Neighboring gene uncharacterized LOC105372065 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from BioSystems

    • DNA Damage Recognition in GG-NER, organism-specific biosystem (from REACTOME)
      DNA Damage Recognition in GG-NER, organism-specific biosystemIn global genome nucleotide excision repair (GG-NER), the DNA damage is recognized by two protein complexes. The first complex consists of XPC, RAD23A or RAD23B, and CETN2. This complex probes the DN...
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystem (from REACTOME)
      Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystemThe DNA damage in GG-NER is recognized by the joint action of two protein complexes. The first complex is composed of XPC, RAD23A or RAD23B and CETN2. The second complex, known as the UV-DDB complex,...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
      Nucleotide Excision Repair, organism-specific biosystemNucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recove...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • UCH proteinases, organism-specific biosystem (from REACTOME)
      UCH proteinases, organism-specific biosystemDUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Hu...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ38183

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Ino80 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MLL1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    INO80 complex subunit C
    Names
    IES6 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098817.2NP_001092287.1  INO80 complex subunit C isoform 1

      See identical proteins and their annotated locations for NP_001092287.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BF475320, BM758571, BQ887287, BY800049
      Consensus CDS
      CCDS45853.1
      UniProtKB/Swiss-Prot
      Q6PI98
      Related
      ENSP00000391457.1, ENST00000441607.6
      Conserved Domains (1) summary
      cl02154
      Location:103223
      YL1_C; YL1 nuclear protein C-terminal domain
    2. NM_001308064.2NP_001294993.1  INO80 complex subunit C isoform 3

      See identical proteins and their annotated locations for NP_001294993.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to isoform 1. The resulting protein (isoform 3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      BF475320, BQ441485
      Consensus CDS
      CCDS77177.1
      UniProtKB/TrEMBL
      K7EIY8
      Related
      ENSP00000464948.1, ENST00000586489.5
      Conserved Domains (1) summary
      cl02154
      Location:12132
      YL1_C; YL1 nuclear protein C-terminal domain
    3. NM_194281.4NP_919257.2  INO80 complex subunit C isoform 2

      See identical proteins and their annotated locations for NP_919257.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      BF475320, BQ887287
      Consensus CDS
      CCDS11914.1
      UniProtKB/Swiss-Prot
      Q6PI98
      Related
      ENSP00000334473.6, ENST00000334598.11
      Conserved Domains (1) summary
      cl02154
      Location:67187
      YL1_C; YL1 nuclear protein C-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

      Range
      35468333..35497960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525812.3XP_011524114.1  INO80 complex subunit C isoform X1

      Conserved Domains (1) summary
      cl02154
      Location:41161
      YL1_C; YL1 nuclear protein C-terminal domain
    2. XM_005258197.5XP_005258254.1  INO80 complex subunit C isoform X2

      See identical proteins and their annotated locations for XP_005258254.1

      UniProtKB/TrEMBL
      K7EIY8
      Conserved Domains (1) summary
      cl02154
      Location:12132
      YL1_C; YL1 nuclear protein C-terminal domain
    3. XM_005258196.5XP_005258253.1  INO80 complex subunit C isoform X2

      See identical proteins and their annotated locations for XP_005258253.1

      UniProtKB/TrEMBL
      K7EIY8
      Conserved Domains (1) summary
      cl02154
      Location:12132
      YL1_C; YL1 nuclear protein C-terminal domain
    4. XM_024451089.1XP_024306857.1  INO80 complex subunit C isoform X2

      Conserved Domains (1) summary
      cl02154
      Location:12132
      YL1_C; YL1 nuclear protein C-terminal domain
    5. XM_017025549.1XP_016881038.1  INO80 complex subunit C isoform X2

      UniProtKB/TrEMBL
      K7EIY8
      Conserved Domains (1) summary
      cl02154
      Location:12132
      YL1_C; YL1 nuclear protein C-terminal domain
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