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    Cd8a CD8 antigen, alpha chain [ Mus musculus (house mouse) ]

    Gene ID: 12525, updated on 18-Jun-2019

    Summary

    Official Symbol
    Cd8aprovided by MGI
    Official Full Name
    CD8 antigen, alpha chainprovided by MGI
    Primary source
    MGI:MGI:88346
    See related
    Ensembl:ENSMUSG00000053977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly-2; Ly-B; Ly-35; Lyt-2; BB154331
    Expression
    Restricted expression toward thymus adult (RPKM 213.1) See more
    Orthologs

    Genomic context

    See Cd8a in Genome Data Viewer
    Location:
    6 C1; 6 32.14 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (71373427..71379171)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (71323421..71329165)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38828 Neighboring gene CD8 antigen, beta chain 1 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene predicted gene, 30582

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2) 
    • Targeted (13)  1 citation

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    MHC class I protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    T cell mediated immunity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    T cell mediated immunity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytotoxic T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytotoxic T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    T-cell surface glycoprotein CD8 alpha chain
    Names
    Lyt-2.1 lymphocyte differentiation antigen (AA at 100)
    T-cell surface glycoprotein Lyt-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081110.2NP_001074579.1  T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_001074579.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC160090
      Consensus CDS
      CCDS39507.1
      UniProtKB/Swiss-Prot
      P01731
      Related
      ENSMUSP00000068123.7, ENSMUST00000066747.13
      Conserved Domains (2) summary
      cd05720
      Location:41147
      Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
      smart00410
      Location:38142
      IG_like; Immunoglobulin like
    2. NM_009857.1NP_033987.1  T-cell surface glycoprotein CD8 alpha chain isoform 2 precursor

      See identical proteins and their annotated locations for NP_033987.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region resulting in a frameshift, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC160090
      Consensus CDS
      CCDS51806.1
      UniProtKB/TrEMBL
      Q8CAX3
      Related
      ENSMUSP00000131873.1, ENSMUST00000172321.2
      Conserved Domains (2) summary
      cd05720
      Location:41147
      Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
      smart00410
      Location:38142
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      71373427..71379171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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