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    Cd3g CD3 antigen, gamma polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 12502, updated on 12-May-2024

    Summary

    Official Symbol
    Cd3gprovided by MGI
    Official Full Name
    CD3 antigen, gamma polypeptideprovided by MGI
    Primary source
    MGI:MGI:88333
    See related
    Ensembl:ENSMUSG00000002033 AllianceGenome:MGI:88333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T3g; Ctg3; Ctg-3
    Summary
    Predicted to enable identical protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in several processes, including positive thymic T cell selection; protein transport; and regulation of lymphocyte apoptotic process. Predicted to act upstream of or within adaptive immune response. Part of alpha-beta T cell receptor complex. Human ortholog(s) of this gene implicated in immunodeficiency 17. Orthologous to human CD3G (CD3g molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 54.5), spleen adult (RPKM 5.5) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Cd3g in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44880870..44891729, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44969572..44980431, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit g Neighboring gene predicted gene, 30934 Neighboring gene ubiquitination factor E4A Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44773592-44773779 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794321-44794504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794585-44794829 Neighboring gene CD3 antigen, delta polypeptide Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44804746-44804978 Neighboring gene CD3 antigen, epsilon polypeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive thymic T cell selection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lymphocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of alpha-beta T cell receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of alpha-beta T cell receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of alpha-beta T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    T-cell surface glycoprotein CD3 gamma chain
    Names
    T-cell receptor T3 gamma chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009850.2NP_033980.1  T-cell surface glycoprotein CD3 gamma chain precursor

      See identical proteins and their annotated locations for NP_033980.1

      Status: VALIDATED

      Source sequence(s)
      AC061963, BC027528, BY224047
      Consensus CDS
      CCDS23123.1
      UniProtKB/Swiss-Prot
      P11942
      UniProtKB/TrEMBL
      Q3U4Y3, Q3UZ65
      Related
      ENSMUSP00000002101.6, ENSMUST00000002101.12
      Conserved Domains (2) summary
      pfam02189
      Location:157176
      ITAM; Immunoreceptor tyrosine-based activation motif
      pfam16680
      Location:40106
      Ig_4; T-cell surface glycoprotein CD3 delta chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44880870..44891729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)