Format

Send to:

Choose Destination
    • Showing Current items.

    WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 124857, updated on 17-Jun-2019

    Summary

    Official Symbol
    WFIKKN2provided by HGNC
    Official Full Name
    WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:30916
    See related
    Ensembl:ENSG00000173714 MIM:610895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GASP-1; WFDC20B; hGASP-1; WFIKKNRP
    Summary
    The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in ovary (RPKM 30.8) and testis (RPKM 1.8) See more
    Orthologs

    Genomic context

    See WFIKKN2 in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50834584..50842353)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48912011..48919709)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ANKRD40 C-terminal like Neighboring gene microRNA 8059 Neighboring gene ribosomal protein L5 pseudogene 33 Neighboring gene TOB1 antisense RNA 1 Neighboring gene transducer of ERBB2, 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metalloendopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor antagonist activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transforming growth factor beta binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transforming growth factor beta binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    roof of mouth development IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
    Names
    WAP four-disulfide core domain 20B
    WAP, FS, Ig, two KU and NTR module related protein
    WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing-related protein
    WFIKKN-related protein
    growth and differentiation factor-associated serum protein 1
    multivalent protease inhibitor protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330341.2NP_001317270.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC091062, AK298172, AY358142, BG197394
      Consensus CDS
      CCDS82159.1
      UniProtKB/Swiss-Prot
      Q8TEU8
      UniProtKB/TrEMBL
      C9J6G4
      Related
      ENSP00000405889.1, ENST00000426127.1
    2. NM_175575.6NP_783165.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_783165.1

      Status: REVIEWED

      Source sequence(s)
      AC091062, AF468657, AY358142, BG221308
      Consensus CDS
      CCDS11575.1
      UniProtKB/Swiss-Prot
      Q8TEU8
      Related
      ENSP00000311184.4, ENST00000311378.4
      Conserved Domains (6) summary
      cd05765
      Location:224304
      Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
      cd00104
      Location:138174
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd03575
      Location:455563
      NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
      pfam07679
      Location:216304
      I-set; Immunoglobulin I-set domain
      pfam00014
      Location:385436
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:4490
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      50834584..50842353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center