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    MSI2 musashi RNA binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 124540, updated on 18-Jun-2019

    Summary

    Official Symbol
    MSI2provided by HGNC
    Official Full Name
    musashi RNA binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:18585
    See related
    Ensembl:ENSG00000153944 MIM:607897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSI2H
    Summary
    This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]
    Expression
    Ubiquitous expression in adrenal (RPKM 11.7), ovary (RPKM 7.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See MSI2 in Genome Data Viewer
    Location:
    17q22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (57255851..57684689)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (55333931..55762050)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 126 pseudogene 1 Neighboring gene A-kinase anchoring protein 1 Neighboring gene uncharacterized LOC101927510 Neighboring gene uncharacterized LOC101927557 Neighboring gene uncharacterized LOC107984993 Neighboring gene uncharacterized LOC101927539 Neighboring gene RNA, 7SL, cytoplasmic 449, pseudogene Neighboring gene RNA, U7 small nuclear 134 pseudogene Neighboring gene coiled-coil domain containing 182

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC3245, FLJ36569

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    poly(U) RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    stem cell development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    polysome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA-binding protein Musashi homolog 2
    Names
    musashi homolog 2
    musashi-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322250.1NP_001309179.1  RNA-binding protein Musashi homolog 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC005325, AI416968, AK295060
      Consensus CDS
      CCDS82168.1
      UniProtKB/TrEMBL
      B4DHE8
      Related
      ENSP00000414671.2, ENST00000416426.6
      Conserved Domains (3) summary
      cd12323
      Location:89162
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:175
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
      cl25887
      Location:13321
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    2. NM_001322251.2NP_001309180.1  RNA-binding protein Musashi homolog 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC007431, AC015883, AC091181
      Conserved Domains (2) summary
      cd12323
      Location:111184
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    3. NM_138962.4NP_620412.1  RNA-binding protein Musashi homolog 2 isoform a

      See identical proteins and their annotated locations for NP_620412.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript, and encodes the longer isoform (a).
      Source sequence(s)
      AC005325, AC015883, AC091181, AI416968, BC001526
      Consensus CDS
      CCDS11596.1
      UniProtKB/Swiss-Prot
      Q96DH6
      Related
      ENSP00000284073.2, ENST00000284073.7
      Conserved Domains (3) summary
      cd12323
      Location:111184
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
      cl25887
      Location:35325
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    4. NM_170721.2NP_733839.1  RNA-binding protein Musashi homolog 2 isoform b

      See identical proteins and their annotated locations for NP_733839.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' and 3' UTR and coding region, compared to variant 1. The resulting isoform (b) contains distinct N- and C-termini compared to isoform a.
      Source sequence(s)
      AC007431, AC015883, AC091181
      Consensus CDS
      CCDS11597.1
      UniProtKB/Swiss-Prot
      Q96DH6
      Related
      ENSP00000313616.3, ENST00000322684.7
      Conserved Domains (2) summary
      cd12323
      Location:107180
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:1893
      RRM1_MSI2; RNA recognition motif 1 in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      57255851..57684689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257014.3XP_005257071.1  RNA-binding protein Musashi homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_005257071.1

      Conserved Domains (3) summary
      TIGR01628
      Location:35343
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:111184
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    2. XM_005257015.3XP_005257072.1  RNA-binding protein Musashi homolog 2 isoform X2

      See identical proteins and their annotated locations for XP_005257072.1

      Conserved Domains (3) summary
      cd12323
      Location:111184
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
      cl25887
      Location:35331
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    3. XM_017024148.1XP_016879637.1  RNA-binding protein Musashi homolog 2 isoform X4

    4. XM_017024147.2XP_016879636.1  RNA-binding protein Musashi homolog 2 isoform X3

      Conserved Domains (3) summary
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
      cl17169
      Location:22153
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl25887
      Location:35312
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    5. XM_011524286.2XP_011522588.1  RNA-binding protein Musashi homolog 2 isoform X6

      See identical proteins and their annotated locations for XP_011522588.1

      Conserved Domains (2) summary
      cd12323
      Location:780
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cl25887
      Location:20239
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    6. XM_017024149.2XP_016879638.1  RNA-binding protein Musashi homolog 2 isoform X5

    7. XM_011524287.3XP_011522589.1  RNA-binding protein Musashi homolog 2 isoform X7

      Conserved Domains (2) summary
      COG0724
      Location:20106
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:1968
      RRM_SF; RNA recognition motif (RRM) superfamily
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