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    NOXO1 NADPH oxidase organizer 1 [ Homo sapiens (human) ]

    Gene ID: 124056, updated on 21-Dec-2019

    Summary

    Official Symbol
    NOXO1provided by HGNC
    Official Full Name
    NADPH oxidase organizer 1provided by HGNC
    Primary source
    HGNC:HGNC:19404
    See related
    Ensembl:ENSG00000196408 MIM:611256
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNX28; P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5
    Summary
    This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
    Expression
    Broad expression in colon (RPKM 2.7), appendix (RPKM 0.9) and 14 other tissues See more
    Orthologs

    Genomic context

    See NOXO1 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1978917..1984027, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2028918..2031704, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 78 Neighboring gene small nucleolar RNA host gene 9 Neighboring gene ring finger protein 151 Neighboring gene transducin beta like 3 Neighboring gene growth factor, augmenter of liver regeneration Neighboring gene synaptogyrin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC20258

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phospholipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    superoxide-generating NADPH oxidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    superoxide-generating NADPH oxidase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of hydrogen peroxide metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of respiratory burst TAS
    Traceable Author Statement
    more info
    PubMed 
    superoxide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    NADPH oxidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NADPH oxidase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    NADPH oxidase organizer 1
    Names
    NADPH oxidase regulatory protein
    Nox organizer 1
    SH3 and PX domain-containing protein 5
    nox-organizing protein 1
    regulatory protein P41NOX

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267721.2NP_001254650.1  NADPH oxidase organizer 1 isoform d

      See identical proteins and their annotated locations for NP_001254650.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) uses an alternate splice site compared to variant a, but maintains the same reading frame. The encoded isoform (d) is longer than isoform a.
      Source sequence(s)
      AK292197, AY191359
      Consensus CDS
      CCDS58406.1
      UniProtKB/Swiss-Prot
      Q8NFA2
      UniProtKB/TrEMBL
      A8K832
      Related
      ENSP00000456800.1, ENST00000566005.5
      Conserved Domains (3) summary
      cd12023
      Location:166221
      SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
      cd12024
      Location:240292
      SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
      cl02563
      Location:3126
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    2. NM_144603.4NP_653204.1  NADPH oxidase organizer 1 isoform a

      See identical proteins and their annotated locations for NP_653204.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) represents the shortest transcript and encodes the shortest isoform (a).
      Source sequence(s)
      BC015917, DB009385
      Consensus CDS
      CCDS10454.1
      UniProtKB/Swiss-Prot
      Q8NFA2
      Related
      ENSP00000346195.4, ENST00000354249.8
      Conserved Domains (3) summary
      cd12023
      Location:161216
      SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
      cd12024
      Location:235287
      SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
      cl02563
      Location:3121
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    3. NM_172167.3NP_751907.1  NADPH oxidase organizer 1 isoform b

      See identical proteins and their annotated locations for NP_751907.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant a. The encoded isoform (b) is longer than isoform a.
      Source sequence(s)
      AF532984, AK292197
      Consensus CDS
      CCDS10455.1
      UniProtKB/Swiss-Prot
      Q8NFA2
      UniProtKB/TrEMBL
      A8K832
      Related
      ENSP00000348435.4, ENST00000356120.8
      Conserved Domains (3) summary
      cd12023
      Location:162217
      SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
      cd12024
      Location:236288
      SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
      cl02563
      Location:3122
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    4. NM_172168.3NP_751908.1  NADPH oxidase organizer 1 isoform c

      See identical proteins and their annotated locations for NP_751908.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) uses two alternate splice sites compared to variant a, but maintains the same reading frame. The encoded isoform (c) is longer than isoform a.
      Source sequence(s)
      AF532985, AK292197
      Consensus CDS
      CCDS42101.1
      UniProtKB/Swiss-Prot
      Q8NFA2
      UniProtKB/TrEMBL
      A8K832
      Related
      ENSP00000380450.4, ENST00000397280.8
      Conserved Domains (3) summary
      cd12023
      Location:167222
      SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
      cd12024
      Location:241293
      SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
      cl02563
      Location:3127
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      1978917..1984027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022927.2XP_016878416.1  NADPH oxidase organizer 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8NFA2
      Conserved Domains (3) summary
      cd12023
      Location:167222
      SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
      cd12024
      Location:241293
      SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
      cl02563
      Location:3127
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    2. XM_005255099.5XP_005255156.1  NADPH oxidase organizer 1 isoform X1

      See identical proteins and their annotated locations for XP_005255156.1

      UniProtKB/Swiss-Prot
      Q8NFA2
      Conserved Domains (3) summary
      cd12023
      Location:167222
      SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
      cd12024
      Location:241293
      SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
      cl02563
      Location:3127
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    3. XM_017022928.1XP_016878417.1  NADPH oxidase organizer 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8NFA2
      Conserved Domains (3) summary
      cd12023
      Location:167222
      SH3_NoxO1_1; First or N-terminal Src homology 3 domain of Nox Organizing protein 1
      cd12024
      Location:241293
      SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
      cl02563
      Location:3127
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
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