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    CCR3 C-C motif chemokine receptor 3 [ Homo sapiens (human) ]

    Gene ID: 1232, updated on 17-Jun-2024

    Summary

    Official Symbol
    CCR3provided by HGNC
    Official Full Name
    C-C motif chemokine receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:1604
    See related
    Ensembl:ENSG00000183625 MIM:601268; AllianceGenome:HGNC:1604
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKR3; CD193; CKR 3; CMKBR3; C C CKR3; CC-CKR-3
    Summary
    The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CCR3 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (46210696..46266706)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (46226558..46282568)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46283872..46308197)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46211627-46212128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46212129-46212628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19795 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_70326 Neighboring gene C-C motif chemokine receptor 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:46280932-46281488 Neighboring gene NANOG hESC enhancer GRCh37_chr3:46285885-46286429 Neighboring gene ubiquinol-cytochrome c reductase core protein 2 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:46386020-46386226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19796 Neighboring gene C-C motif chemokine receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
    EBI GWAS Catalog
    Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children.
    EBI GWAS Catalog
    Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
    EBI GWAS Catalog
    Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog
    Newly identified genetic risk variants for celiac disease related to the immune response.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The coreceptor-binding site in HIV-1 gp120 is centered around an anti-parallel beta-sheet structure 'bridging sheet domain'; mutations in and adjacent to this domain affect the use of coreceptors CCR3 and CCR8 by gp120 for virus entry PubMed
    env CCR3 is an alternative coreceptor usage by R5-tropic HIV-1 type C gp120/gp41, although its usage frequency is less than that of CCR5 coreceptor PubMed
    env HIV-1 gp120 utilization of CCR3 as a coreceptor facilitates infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, inhibits infection by these isolates PubMed
    env Utilization of CCR3 and CCR5 as coreceptors of HIV-1 binding/fusion depends upon the sequence of the third variable (V3) region of the HIV-1 gp120 exterior envelope glycoprotein PubMed
    env Macrophage-tropic HIV-1 can use CCR2b, and to a lesser extent CCR3, STRL33, and APJ, to infect cells; the V1/2 region of HIV-1 gp120 plays a more important role in governing the use of CCR2b, CCR3, STRL33, and APJ than for CXCR4 PubMed
    env Amino acid N356 in conserved region 3 of HIV-1 gp120 and amino acids R440 and N448 in conserved region 4 of gp120 are three amino-acid determinants for CCR3 use as a coreceptor for HIV-1 entry into cells PubMed
    env HIV-1 isolates showing CCR3 tropism are particularly efficient in using CMKLR1/ChemR23 as a co-receptor; some HIV-2 and SIV isolates also use CMKLR1/ChemR23 PubMed
    Envelope transmembrane glycoprotein gp41 env CCR3 is an alternative coreceptor usage by R5-tropic HIV-1 type C gp120/gp41, although its usage frequency is less than that of CCR5 coreceptor PubMed
    Nef nef HIV-1 Nef induces variable levels of CCR3 downregulation in different cell types PubMed
    Tat tat HIV-1 Tat-mediated activation of the CB2R leads to altered expression and compartmentation of the beta-chemokine receptor CCR-3 PubMed
    tat HIV-1 Tat-induced platelet activation requires the chemokine receptor CCR3 and beta3-integrin expression on platelets and calcium flux in platelets PubMed
    tat HIV-1 Tat binds to CCR3 and displaces MCP-3 from this beta-chemokine receptor, an effect mediated by Tat amino acids 24-51 PubMed
    tat HIV-1 Tat upregulates CCR3 expression on monocytes/macrophages, Fc epsilonRI+ cells and blood brain barrier cultures, and acts as a potent chemoattractant, indicating a role for Tat in HIV-1 pathogenesis and in promoting HIV-1 infectivity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102841

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-C chemokine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    C-C chemokine receptor type 3
    Names
    C-C CKR-3
    CC chemokine receptor 3
    CCR-3
    b-chemokine receptor
    chemokine (C-C motif) receptor 3
    eosinophil CC chemokine receptor 3
    eosinophil eotaxin receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164680.2NP_001158152.1  C-C chemokine receptor type 3 isoform 3

      See identical proteins and their annotated locations for NP_001158152.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate internal exon, which includes an upstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (3) has a longer N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC104439, AF262303
      UniProtKB/TrEMBL
      Q8TDP4
      Conserved Domains (1) summary
      pfam00001
      Location:75319
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_001837.4NP_001828.1  C-C chemokine receptor type 3 isoform 1

      See identical proteins and their annotated locations for NP_001828.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. It encodes the same isoform (1) as variant 2.
      Source sequence(s)
      AC104439, AF262302
      Consensus CDS
      CCDS2738.1
      UniProtKB/Swiss-Prot
      B3KVQ1, F5GWL6, P51677, Q15748, Q2YDB9, Q86WD2, Q8TDP6, Q9ULY8
      Conserved Domains (2) summary
      cd14964
      Location:3761
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:35312
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. NM_178328.1NP_847898.1  C-C chemokine receptor type 3 isoform 2

      See identical proteins and their annotated locations for NP_847898.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate internal exon, which includes an upstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) has a longer N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC104439, AF262301
      Consensus CDS
      CCDS54574.1
      UniProtKB/Swiss-Prot
      P51677
      Related
      ENSP00000441600.1, ENST00000545097.1
      Conserved Domains (1) summary
      pfam00001
      Location:78322
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. NM_178329.3NP_847899.1  C-C chemokine receptor type 3 isoform 1

      See identical proteins and their annotated locations for NP_847899.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, as compared to variant 1. Both variants encode the same isoform 1.
      Source sequence(s)
      AC104439, BC130320
      Consensus CDS
      CCDS2738.1
      UniProtKB/Swiss-Prot
      B3KVQ1, F5GWL6, P51677, Q15748, Q2YDB9, Q86WD2, Q8TDP6, Q9ULY8
      Related
      ENSP00000379271.2, ENST00000395940.3
      Conserved Domains (2) summary
      cd14964
      Location:3761
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:35312
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      46210696..46266706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712960.4XP_006713023.1  C-C chemokine receptor type 3 isoform X2

      See identical proteins and their annotated locations for XP_006713023.1

      UniProtKB/Swiss-Prot
      B3KVQ1, F5GWL6, P51677, Q15748, Q2YDB9, Q86WD2, Q8TDP6, Q9ULY8
      Related
      ENSP00000350003.2, ENST00000357422.2
      Conserved Domains (2) summary
      cd14964
      Location:3761
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:35312
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_017005685.2XP_016861174.1  C-C chemokine receptor type 3 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      46226558..46282568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345169.1XP_054201144.1  C-C chemokine receptor type 3 isoform X2

      UniProtKB/Swiss-Prot
      B3KVQ1, F5GWL6, P51677, Q15748, Q2YDB9, Q86WD2, Q8TDP6, Q9ULY8
    2. XM_054345168.1XP_054201143.1  C-C chemokine receptor type 3 isoform X1