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    CCR1 C-C motif chemokine receptor 1 [ Homo sapiens (human) ]

    Gene ID: 1230, updated on 16-Aug-2021

    Summary

    Official Symbol
    CCR1provided by HGNC
    Official Full Name
    C-C motif chemokine receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:1602
    See related
    Ensembl:ENSG00000163823 MIM:601159
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1
    Summary
    This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 27.8), spleen (RPKM 15.6) and 17 other tissues See more
    Orthologs
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    Genomic context

    See CCR1 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (46201711..46208313, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46243202..46249804, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1914 Neighboring gene uncharacterized LOC105377067 Neighboring gene FLT1 pseudogene 1 Neighboring gene C-C motif chemokine receptor 3 Neighboring gene ubiquinol-cytochrome c reductase core protein 2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
    GeneReviews: Not available
    Multiple common variants for celiac disease influencing immune gene expression.
    GeneReviews: Not available
    Newly identified genetic risk variants for celiac disease related to the immune response.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 from CXCR4-tropic subtype E viruses isolated in Thailand associates with and uses at least one of the following coreceptors for virus entry: CCR8, CCR1, CCR2b, or CX3CR1 PubMed
    Nef nef HIV-1 Nef induces variable levels of CCR1 downregulation in different cell types PubMed
    Tat tat HIV-1 Tat protein modulates CCR1 and CCR3 mRNA expression in blood-brain barrier cultures, suggesting HIV-induced molecules can manipulate the surface receptor expression of the blood-brain barrier for their preferential entry into brain PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables C-C chemokine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables C-C chemokine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chemokine (C-C motif) ligand 5 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chemokine (C-C motif) ligand 5 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chemokine (C-C motif) ligand 7 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chemokine (C-C motif) ligand 7 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chemokine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chemotaxis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in dendritic cell chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to wounding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    C-C chemokine receptor type 1
    Names
    C-C CKR-1
    CC-CKR-1
    CCR-1
    LD78 receptor
    MIP-1alpha-R
    RANTES receptor
    RANTES-R
    chemokine (C-C motif) receptor 1
    macrophage inflammatory protein 1-alpha receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001295.3NP_001286.1  C-C chemokine receptor type 1

      See identical proteins and their annotated locations for NP_001286.1

      Status: REVIEWED

      Source sequence(s)
      AI089760, BC064991, BX337412, CK903574
      Consensus CDS
      CCDS2737.1
      UniProtKB/Swiss-Prot
      P32246
      UniProtKB/TrEMBL
      Q5U003
      Related
      ENSP00000296140.3, ENST00000296140.4
      Conserved Domains (1) summary
      cd15183
      Location:35312
      7tmA_CCR1; CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      46201711..46208313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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