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    Bcl3 B cell leukemia/lymphoma 3 [ Mus musculus (house mouse) ]

    Gene ID: 12051, updated on 4-Jun-2019

    Summary

    Official Symbol
    Bcl3provided by MGI
    Official Full Name
    B cell leukemia/lymphoma 3provided by MGI
    Primary source
    MGI:MGI:88140
    See related
    Ensembl:ENSMUSG00000053175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bcl-3; AI528691
    Expression
    Biased expression in duodenum adult (RPKM 114.5), small intestine adult (RPKM 82.2) and 11 other tissues See more
    Orthologs

    Genomic context

    See Bcl3 in Genome Data Viewer
    Location:
    7 A3; 7 9.95 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (19808462..19822767, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (20393811..20408104, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34744 Neighboring gene basal cell adhesion molecule Neighboring gene Casitas B-lineage lymphoma c Neighboring gene predicted gene 16174 Neighboring gene predicted gene, 34891 Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 16 Neighboring gene predicted gene, 19345

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (8)  1 citation
    • Chemically induced (ENU) (3) 

    Pathways from BioSystems

    • TNF signaling pathway, organism-specific biosystem (from KEGG)
      TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNF signaling pathway, conserved biosystem (from KEGG)
      TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
      TNF-alpha NF-kB Signaling Pathway

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    T-helper 1 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T-helper 2 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    antimicrobial humoral response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    follicular dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germinal center formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    humoral immune response mediated by circulating immunoglobulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    marginal zone B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-8 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-10 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to UV-C ISO
    Inferred from Sequence Orthology
    more info
     
    response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Bcl3-Bcl10 complex ISO
    Inferred from Sequence Orthology
    more info
     
    Bcl3/NF-kappaB2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    B-cell lymphoma 3 protein homolog
    Names
    B-cell CLL/lymphoma 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033601.3NP_291079.2  B-cell lymphoma 3 protein homolog

      See identical proteins and their annotated locations for NP_291079.2

      Status: VALIDATED

      Source sequence(s)
      AF067774, AI528691, BY749796
      Consensus CDS
      CCDS20914.2
      UniProtKB/Swiss-Prot
      Q9Z2F6
      Related
      ENSMUSP00000113851.1, ENSMUST00000120537.7
      Conserved Domains (4) summary
      cd00204
      Location:195324
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:204300
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:152207
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:236267
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      19808462..19822767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539487.3XP_006539550.1  B-cell lymphoma 3 protein homolog isoform X1

      Conserved Domains (4) summary
      cd00204
      Location:195324
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:204300
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:152207
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:236267
      ANK; ANK repeat [structural motif]
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