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    C10orf90 chromosome 10 open reading frame 90 [ Homo sapiens (human) ]

    Gene ID: 118611, updated on 17-Jun-2019

    Summary

    Official Symbol
    C10orf90provided by HGNC
    Official Full Name
    chromosome 10 open reading frame 90provided by HGNC
    Primary source
    HGNC:HGNC:26563
    See related
    Ensembl:ENSG00000154493 MIM:617735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FATS; bA422P15.2
    Expression
    Biased expression in testis (RPKM 1.4), brain (RPKM 1.2) and 2 other tissues See more
    Orthologs

    Genomic context

    See C10orf90 in Genome Data Viewer
    Location:
    10q26.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (126424997..126670510, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (128113566..128213444, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene secretion associated Ras related GTPase 1A pseudogene 2 Neighboring gene uncharacterized LOC112267914 Neighboring gene long intergenic non-protein coding RNA 601 Neighboring gene uncharacterized LOC728158 Neighboring gene uncharacterized LOC105378549 Neighboring gene uncharacterized LOC105378548 Neighboring gene uncharacterized LOC105378550 Neighboring gene uncharacterized LOC107984059 Neighboring gene dedicator of cytokinesis 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ32938

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    alpha-actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    (E2-independent) E3 ubiquitin-conjugating enzyme FATS
    Names
    E2/E3 hybrid ubiquitin-protein ligase FATS
    centrosomal protein C10orf90
    fragile-site associated tumor suppressor homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004298.3NP_001004298.2  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 2

      See identical proteins and their annotated locations for NP_001004298.2

      Status: VALIDATED

      Source sequence(s)
      AF435960, AK297577, AL705062, BC034828, CA423069, DB076049
      Consensus CDS
      CCDS31310.1
      UniProtKB/Swiss-Prot
      Q96M02
      Related
      ENSP00000284694.7, ENST00000284694.11
      Conserved Domains (1) summary
      pfam15309
      Location:568697
      ALMS_motif; ALMS motif
    2. NM_001350921.1NP_001337850.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 1

      Status: VALIDATED

      Source sequence(s)
      AF435960, AK297577, AL705062, BC034828, CA423069, DA524526
      Conserved Domains (1) summary
      pfam15309
      Location:665794
      ALMS_motif; ALMS motif
    3. NM_001350922.1NP_001337851.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 3

      Status: VALIDATED

      Source sequence(s)
      AF435960, AL705062, BC034828, CA423069, DA524526
      Conserved Domains (1) summary
      pfam15309
      Location:568697
      ALMS_motif; ALMS motif
    4. NM_001350923.1NP_001337852.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 4

      Status: VALIDATED

      Source sequence(s)
      AI336978, AL589787, AL705062, BC034828, DA524526, DB512365

    RNA

    1. NR_146939.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF435960, AK297577, AL589787, AL705062, BC034828, CA423069, DA524526

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      126424997..126670510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539217.2XP_011537519.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X1

      Conserved Domains (1) summary
      pfam15309
      Location:595724
      ALMS_motif; ALMS motif
    2. XM_011539223.2XP_011537525.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X2

      See identical proteins and their annotated locations for XP_011537525.1

      Related
      ENSP00000349318.3, ENST00000356858.7
      Conserved Domains (1) summary
      pfam15309
      Location:521650
      ALMS_motif; ALMS motif

    RNA

    1. XR_002956950.1 RNA Sequence

    2. XR_002956946.1 RNA Sequence

    3. XR_002956955.1 RNA Sequence

    4. XR_002956947.1 RNA Sequence

    5. XR_002956951.1 RNA Sequence

    6. XR_002956954.1 RNA Sequence

    7. XR_002956953.1 RNA Sequence

    8. XR_002956949.1 RNA Sequence

    9. XR_002956952.1 RNA Sequence

    10. XR_002956948.1 RNA Sequence

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