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    Aqp2 aquaporin 2 [ Mus musculus (house mouse) ]

    Gene ID: 11827, updated on 10-Oct-2019

    Summary

    Official Symbol
    Aqp2provided by MGI
    Official Full Name
    aquaporin 2provided by MGI
    Primary source
    MGI:MGI:1096865
    See related
    Ensembl:ENSMUSG00000023013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cph; jpk; AQP-CD; WCH-CD
    Expression
    Restricted expression toward kidney adult (RPKM 289.8) See more
    Orthologs

    Genomic context

    See Aqp2 in Genome Data Viewer
    Location:
    15 F1; 15 56.13 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99579056..99584545)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (99409487..99414976)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene Fas apoptotic inhibitory molecule 2 Neighboring gene predicted gene 5808 Neighboring gene predicted gene, 34765 Neighboring gene aquaporin 5 Neighboring gene aquaporin 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    congenital progressive hydronephrosis
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    glycerol transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    water channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    water channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    water transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to mercury ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to water deprivation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to water deprivation ISO
    Inferred from Sequence Orthology
    more info
     
    glycerol transport ISO
    Inferred from Sequence Orthology
    more info
     
    metanephric collecting duct development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    renal water homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    renal water transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    water transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    water transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    exocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of endosome membrane IC
    Inferred by Curator
    more info
    PubMed 
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane ISM
    Inferred from Sequence Model
    more info
    PubMed 
    integral component of plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lumenal side of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    recycling endosome membrane IC
    Inferred by Curator
    more info
    PubMed 
    rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    aquaporin-2
    Names
    ADH water channel
    AQP-2
    aquaporin-CD
    collecting duct water channel protein
    water channel protein for renal collecting duct

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009699.3NP_033829.3  aquaporin-2

      See identical proteins and their annotated locations for NP_033829.3

      Status: VALIDATED

      Source sequence(s)
      AK142567
      Consensus CDS
      CCDS27822.1
      UniProtKB/Swiss-Prot
      P56402
      UniProtKB/TrEMBL
      Q3UQD4
      Related
      ENSMUSP00000023752.4, ENSMUST00000023752.5
      Conserved Domains (1) summary
      pfam00230
      Location:3219
      MIP; Major intrinsic protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p6 C57BL/6J

      Range
      99579056..99584545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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