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    Ppat phosphoribosyl pyrophosphate amidotransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117544, updated on 21-Jul-2018

    Summary

    Official Symbol
    Ppatprovided by RGD
    Official Full Name
    phosphoribosyl pyrophosphate amidotransferaseprovided by RGD
    Primary source
    RGD:620237
    See related
    Ensembl:ENSRNOG00000002128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atase
    Summary
    catalyzes the irreversible reaction between 5- phosphoribosyl-1-pyrophosphate, glutamine, and water to form 5P-phosphoribosyl-1-amine, glutamate, and inorganic pyrophosphate [RGD, Feb 2006]
    Expression
    Biased expression in Muscle (RPKM 207.3), Heart (RPKM 207.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Ppat in Genome Data Viewer
    Location:
    14p11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (33580541..33614919)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (33371454..33405854)

    Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene nucleolin-like Neighboring gene signal recognition particle subunit SRP72-like Neighboring gene zinc finger and SCAN domain-containing protein 20-like Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene uncharacterized LOC108352739 Neighboring gene uncharacterized LOC102552854 Neighboring gene uncharacterized LOC108352737 Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene hypothetical LOC289568

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC93251

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    amidophosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    G1/S transition of mitotic cell cycle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glutamine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kidney development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    lactation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    maternal process involved in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    purine ribonucleoside monophosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ribose phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    amidophosphoribosyltransferase
    Names
    GPAT
    glutamine phosphoribosylpyrophosphate amidotransferase
    NP_476546.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057198.2NP_476546.1  amidophosphoribosyltransferase precursor

      See identical proteins and their annotated locations for NP_476546.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086999
      UniProtKB/Swiss-Prot
      P35433
      Related
      ENSRNOP00000002905.2, ENSRNOT00000002905.3
      Conserved Domains (3) summary
      cd06223
      Location:306442
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
      COG0034
      Location:8515
      PurF; Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]
      cd00715
      Location:12295
      GPATase_N; Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

      Range
      33580541..33614919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000082.1 Alternate Rn_Celera

      Range
      30529492..30563868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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