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    Cflar CASP8 and FADD-like apoptosis regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117279, updated on 10-Oct-2019

    Summary

    Official Symbol
    Cflarprovided by RGD
    Official Full Name
    CASP8 and FADD-like apoptosis regulatorprovided by RGD
    Primary source
    RGD:620847
    See related
    Ensembl:ENSRNOG00000012473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Flip
    Summary
    an anti-apoptosis protein [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 156.3), Lung (RPKM 134.8) and 9 other tissues See more
    Orthologs

    Genomic context

    See Cflar in Genome Data Viewer
    Location:
    9q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65534608..65586395)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (65342359..65390152)

    Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 126, member B Neighboring gene barrier-to-autointegration factor-like Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene uncharacterized LOC100909946 Neighboring gene uncharacterized LOC102550737 Neighboring gene caspase 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC108616

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    death receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protease binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to dexamethasone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to epidermal growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to estradiol stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to nitric oxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cellular response to transforming growth factor beta stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of epithelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of hepatocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of myoblast fusion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of necroptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glomerular mesangial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hepatocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of skeletal muscle satellite cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of skeletal muscle satellite cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to testosterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skeletal muscle atrophy IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle atrophy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    skeletal muscle tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    skeletal myofibril assembly IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal myofibril assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    CD95 death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    death-inducing signaling complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ripoptosome IEA
    Inferred from Electronic Annotation
    more info
     
    ripoptosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    CASP8 and FADD-like apoptosis regulator

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033864.3NP_001029036.1  CASP8 and FADD-like apoptosis regulator isoform 1

      See identical proteins and their annotated locations for NP_001029036.1

      Status: VALIDATED

      Source sequence(s)
      AC123462
      UniProtKB/TrEMBL
      C0H5Y5
      Related
      ENSRNOP00000016730.3, ENSRNOT00000016730.5
      Conserved Domains (3) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:249479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    2. NM_057138.3NP_476479.1  CASP8 and FADD-like apoptosis regulator isoform 2

      See identical proteins and their annotated locations for NP_476479.1

      Status: VALIDATED

      Source sequence(s)
      AC123462
      UniProtKB/TrEMBL
      C0H5Y5, Q99MZ5
      Conserved Domains (2) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

      Range
      65534608..65586395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244949.3XP_006245011.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_006245011.1

      UniProtKB/TrEMBL
      C0H5Y5
      Conserved Domains (3) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:249479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    2. XM_006244946.3XP_006245008.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_006245008.1

      UniProtKB/TrEMBL
      C0H5Y5
      Conserved Domains (3) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:249479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    3. XM_006244947.3XP_006245009.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_006245009.1

      UniProtKB/TrEMBL
      C0H5Y5
      Conserved Domains (3) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:249479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    4. XM_006244948.3XP_006245010.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_006245010.1

      UniProtKB/TrEMBL
      C0H5Y5
      Conserved Domains (3) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:249479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    5. XM_017596249.1XP_017451738.1  CASP8 and FADD-like apoptosis regulator isoform X3

      Conserved Domains (3) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:249268
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    6. XM_006244950.3XP_006245012.1  CASP8 and FADD-like apoptosis regulator isoform X2

      Conserved Domains (2) summary
      cd08340
      Location:46124
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:197427
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    Alternate Rn_Celera

    Genomic

    1. AC_000077.1 Alternate Rn_Celera

      Range
      57626739..57673502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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