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    PPP1R27 protein phosphatase 1 regulatory subunit 27 [ Homo sapiens (human) ]

    Gene ID: 116729, updated on 27-Nov-2024

    Summary

    Official Symbol
    PPP1R27provided by HGNC
    Official Full Name
    protein phosphatase 1 regulatory subunit 27provided by HGNC
    Primary source
    HGNC:HGNC:16813
    See related
    Ensembl:ENSG00000182676 AllianceGenome:HGNC:16813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DYSFIP1
    Summary
    Enables phosphatase binding activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in prostate (RPKM 3.7), esophagus (RPKM 0.9) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PPP1R27 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81833492..81835050, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82700657..82702215, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79791368..79792926, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376789 Neighboring gene glucagon receptor Neighboring gene Sharpr-MPRA regulatory region 4607 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79781934-79782157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79783828-79784461 Neighboring gene MAPK regulated corepressor interacting protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79789117-79789630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79789631-79790144 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79791171-79791684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79792198-79792710 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79792711-79793223 Neighboring gene prolyl 4-hydroxylase subunit beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79813353-79813852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9154 Neighboring gene uncharacterized LOC124904086 Neighboring gene Sharpr-MPRA regulatory region 9355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79823980-79824608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79825239-79825867 Neighboring gene Rho GDP dissociation inhibitor alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 27
    Names
    dysferlin interacting protein 1
    dysferlin-interacting protein 1 (toonin)
    toonin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007533.4NP_001007534.1  protein phosphatase 1 regulatory subunit 27

      See identical proteins and their annotated locations for NP_001007534.1

      Status: VALIDATED

      Source sequence(s)
      AA722724, BC112094, BI826571, DA894509
      Consensus CDS
      CCDS32767.1
      UniProtKB/Swiss-Prot
      Q86WC6
      Related
      ENSP00000331065.4, ENST00000330261.5
      Conserved Domains (2) summary
      cd00204
      Location:38147
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:6394
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      81833492..81835050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160021.1 Reference GRCh38.p14 PATCHES

      Range
      46985..48543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82700657..82702215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)