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    Adora1 adenosine A1 receptor [ Mus musculus (house mouse) ]

    Gene ID: 11539, updated on 23-Apr-2019

    Summary

    Official Symbol
    Adora1provided by MGI
    Official Full Name
    adenosine A1 receptorprovided by MGI
    Primary source
    MGI:MGI:99401
    See related
    Ensembl:ENSMUSG00000042429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ri; A1R; A1AR; AA1R; ARA1; A1-AR; AI848715; BB176431
    Expression
    Biased expression in adrenal adult (RPKM 63.0), cerebellum adult (RPKM 30.8) and 13 other tissues See more
    Orthologs

    Genomic context

    See Adora1 in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (134199215..134235457, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (136095799..136132008, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46158 Neighboring gene chitinase-like 1 Neighboring gene myosin binding protein H Neighboring gene predicted gene, 32221 Neighboring gene myogenin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G protein-coupled adenosine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein beta/gamma-subunit complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    heterotrimeric G-protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    purine nucleoside binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    adenosine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cognition ISO
    Inferred from Sequence Orthology
    more info
     
    detection of temperature stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory postsynaptic potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of circadian sleep/wake cycle, non-REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of circadian sleep/wake cycle, sleep ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of leukocyte migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of long-term synaptic depression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mucus secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neurotrophin production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nucleoside transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptide secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cardiac muscle cell contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of respiratory gaseous exchange by neurological system process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    relaxation of vascular smooth muscle ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    temperature homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    axolemma ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    calyx of Held ISO
    Inferred from Sequence Orthology
    more info
     
    cell body ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endomembrane system ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008533.3NP_001008533.1  adenosine receptor A1 isoform a

      See identical proteins and their annotated locations for NP_001008533.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC137104, AK045729, BY257408, DV552876
      Consensus CDS
      CCDS15305.1
      UniProtKB/Swiss-Prot
      Q60612
      Related
      ENSMUSP00000043522.6, ENSMUST00000038191.7
      Conserved Domains (2) summary
      cd14964
      Location:1236
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10299
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_001039510.2NP_001034599.1  adenosine receptor A1 isoform a

      See identical proteins and their annotated locations for NP_001034599.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1, 2, and 3 encode the same protein (isoform a).
      Source sequence(s)
      AC137104, AK038774, AK134532, DV552876
      Consensus CDS
      CCDS15305.1
      UniProtKB/Swiss-Prot
      Q60612
      UniProtKB/TrEMBL
      Q8CAH1
      Related
      ENSMUSP00000083656.4, ENSMUST00000086465.5
      Conserved Domains (2) summary
      cd14964
      Location:1236
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10299
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. NM_001282945.1NP_001269874.1  adenosine receptor A1 isoform a

      See identical proteins and their annotated locations for NP_001269874.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. Variants 1, 2, and 3 encode the same protein (isoform a).
      Source sequence(s)
      AC137104, AU080986, DV552876
      Consensus CDS
      CCDS15305.1
      UniProtKB/Swiss-Prot
      Q60612
      Conserved Domains (2) summary
      cd14964
      Location:1236
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10299
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    4. NM_001291928.1NP_001278857.1  adenosine receptor A1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 2. The encoded protein (isoform b) has a distinct N-terminus and is shorter, compared to isoform a.
      Source sequence(s)
      AC137104, AK045729, BC079624, BY737264, DV552876
      UniProtKB/Swiss-Prot
      Q60612
      UniProtKB/TrEMBL
      Q6AXD8
      Conserved Domains (1) summary
      pfam00001
      Location:23198
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    5. NM_001291930.1NP_001278859.1  adenosine receptor A1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. The encoded protein (isoform c) is shorter, compared to isoform a.
      Source sequence(s)
      AK134532, AK134709, AK141531, BC058421, DV552876
      UniProtKB/TrEMBL
      Q3URG8, Q3UYG0
      Conserved Domains (1) summary
      pfam00001
      Location:58146
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      134199215..134235457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529079.2XP_006529142.1  adenosine receptor A1 isoform X1

      See identical proteins and their annotated locations for XP_006529142.1

      UniProtKB/Swiss-Prot
      Q60612
      Conserved Domains (2) summary
      cd14964
      Location:1236
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10299
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_009629.3: Suppressed sequence

      Description
      NM_009629.3: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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