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    GBP5 guanylate binding protein 5 [ Homo sapiens (human) ]

    Gene ID: 115362, updated on 15-Jun-2019

    Summary

    Official Symbol
    GBP5provided by HGNC
    Official Full Name
    guanylate binding protein 5provided by HGNC
    Primary source
    HGNC:HGNC:19895
    See related
    Ensembl:ENSG00000154451 MIM:611467
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GBP-5
    Summary
    This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
    Expression
    Biased expression in appendix (RPKM 33.2), lymph node (RPKM 19.8) and 11 other tissues See more
    Orthologs

    Genomic context

    See GBP5 in Genome Data Viewer
    Location:
    1p22.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (89258950..89272861, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89724633..89738544, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985076 Neighboring gene uncharacterized LOC105378843 Neighboring gene guanylate binding protein family member 6 pseudogene Neighboring gene chromosome 11 open reading frame 74 pseudogene Neighboring gene guanylate binding protein family member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 assembly is restricted by GBP5 in HEK293T cells, SupT1 cells, primary PBMC, and macrophages as shown through mutational analysis (C583), overexpression, and siRNA knockdown of GBP5 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Nef may antagonize restriction activity of GBP5 against production of infectious wild-type HIV-1 PubMed
    Tat tat HIV-1 Tat upregulates the expression of guanylate binding protein 5 (GBP5) in human primary T cells PubMed
    Vif vif HIV-1 Vif downregulates the expression of guanylate binding protein 5 (GBP5) in Vif-expression T cells PubMed
    Vpr vpr Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpr may antagonize restriction activity of GBP5 against production of infectious wild-type HIV-1 PubMed
    Vpu vpu Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpu may antagonize restriction activity of GBP5 against production of infectious wild-type HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: GBP4

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to interferon-gamma IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to interferon-gamma IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1 beta secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-18 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of NLRP3 inflammasome complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytokine production involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane HDA PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    guanylate-binding protein 5
    Names
    GBP-TA antigen
    GTP-binding protein 5
    guanine nucleotide-binding protein 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052816.1 RefSeqGene

      Range
      5001..18912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134486.3NP_001127958.1  guanylate-binding protein 5

      See identical proteins and their annotated locations for NP_001127958.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC099063, AF430642, AF430643, CD367361
      Consensus CDS
      CCDS722.1
      UniProtKB/Swiss-Prot
      Q96PP8
      Related
      ENSP00000403010.1, ENST00000443807.1
      Conserved Domains (2) summary
      pfam02263
      Location:18280
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:282574
      GBP_C; Guanylate-binding protein, C-terminal domain
    2. NM_052942.4NP_443174.1  guanylate-binding protein 5

      See identical proteins and their annotated locations for NP_443174.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC099063, AF430642, CD367361
      Consensus CDS
      CCDS722.1
      UniProtKB/Swiss-Prot
      Q96PP8
      Related
      ENSP00000359488.3, ENST00000370459.7
      Conserved Domains (2) summary
      pfam02263
      Location:18280
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:282574
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      89258950..89272860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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