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    VASN vasorin [ Homo sapiens (human) ]

    Gene ID: 114990, updated on 17-Jun-2024

    Summary

    Official Symbol
    VASNprovided by HGNC
    Official Full Name
    vasorinprovided by HGNC
    Primary source
    HGNC:HGNC:18517
    See related
    Ensembl:ENSG00000168140 MIM:608843; AllianceGenome:HGNC:18517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLITL2
    Summary
    Enables transforming growth factor beta binding activity. Involved in negative regulation of epithelial to mesenchymal transition and negative regulation of transforming growth factor beta receptor signaling pathway. Located in cell surface and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta (RPKM 16.9), kidney (RPKM 16.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See VASN in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4371848..4383538)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4401028..4412717)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4421849..4433539)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4374751-4375535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4378569-4379569 Neighboring gene GLIS family zinc finger 2 Neighboring gene GLIS2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4389543-4390289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4390290-4391035 Neighboring gene CORO7-PAM16 readthrough Neighboring gene MPRA-validated peak2471 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4397350-4397850 Neighboring gene presequence translocase associated motor 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4415328-4415828 Neighboring gene coronin 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4419155-4419654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4421231-4422056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4424664-4425443 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4425537-4426318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4426319-4427098 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4428659-4429440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4433428-4434269 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4440665-4441216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4441217-4441770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4452006-4452742 Neighboring gene uncharacterized LOC124903635 Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4499977-4500772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4505719-4506689

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transforming growth factor beta binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    vasorin
    Names
    protein slit-like 2
    slit-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138440.3NP_612449.2  vasorin precursor

      See identical proteins and their annotated locations for NP_612449.2

      Status: VALIDATED

      Source sequence(s)
      AC012676, BC013767, BC068575
      Consensus CDS
      CCDS10514.1
      UniProtKB/Swiss-Prot
      Q6EMK4, Q6UXL4, Q6UXL5, Q96CX1
      Related
      ENSP00000306864.3, ENST00000304735.4
      Conserved Domains (7) summary
      smart00013
      Location:2354
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:298349
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:3456
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00008
      Location:409440
      EGF; EGF-like domain
      pfam00041
      Location:466535
      fn3; Fibronectin type III domain
      pfam12799
      Location:76117
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:101158
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      4371848..4383538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187608.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      74171..85861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      4401028..4412717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)