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    GPRASP2 G protein-coupled receptor associated sorting protein 2 [ Homo sapiens (human) ]

    Gene ID: 114928, updated on 5-Sep-2021

    Summary

    Official Symbol
    GPRASP2provided by HGNC
    Official Full Name
    G protein-coupled receptor associated sorting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:25169
    See related
    Ensembl:ENSG00000158301 MIM:300969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DFNX7; GASP2
    Summary
    The protein encoded by this gene is a member of a family that regulates the activity of G protein-coupled receptors (GPCRs). The encoded protein has been shown to be capable of interacting with several GPCRs, including the M1 muscarinic acetylcholine receptor and the calcitonin receptor. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
    Expression
    Broad expression in brain (RPKM 5.6), ovary (RPKM 5.0) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GPRASP2 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (102712448..102717733)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101967376..101972661)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ARMCX5-GPRASP2 readthrough Neighboring gene RNA, U6 small nuclear 589, pseudogene Neighboring gene BEN domain containing 7 pseudogene 1 Neighboring gene basic helix-loop-helix family member b9 Neighboring gene long intergenic non-protein coding RNA 630 Neighboring gene MT-ND1 pseudogene 32

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough ARMCX5-GPRASP2

    Readthrough gene: ARMCX5-GPRASP2, Included gene: GPRASP1, Included gene: ARMCX5, Included gene: BHLHB9, Included gene: LINC00630

    Homology

    Clone Names

    • FLJ35662, FLJ37327

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in hematopoietic stem cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    G-protein coupled receptor-associated sorting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021322.1 RefSeqGene

      Range
      5120..10405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001004051.4NP_001004051.1  G-protein coupled receptor-associated sorting protein 2

      See identical proteins and their annotated locations for NP_001004051.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AK123832, AL522674, BC051707
      Consensus CDS
      CCDS14501.1
      UniProtKB/Swiss-Prot
      Q96D09
      UniProtKB/TrEMBL
      B3KW05
      Related
      ENSP00000507692.1, ENST00000483720.6
      Conserved Domains (2) summary
      pfam04826
      Location:593837
      Arm_2; Armadillo-like
      cl26386
      Location:1163
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    2. NM_001184874.3NP_001171803.1  G-protein coupled receptor-associated sorting protein 2

      See identical proteins and their annotated locations for NP_001171803.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AK123832, BC051707, DA389655
      Consensus CDS
      CCDS14501.1
      UniProtKB/Swiss-Prot
      Q96D09
      UniProtKB/TrEMBL
      B3KW05
      Related
      ENSP00000437872.1, ENST00000543253.6
      Conserved Domains (2) summary
      pfam04826
      Location:593837
      Arm_2; Armadillo-like
      cl26386
      Location:1163
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    3. NM_001184875.3NP_001171804.1  G-protein coupled receptor-associated sorting protein 2

      See identical proteins and their annotated locations for NP_001171804.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AK123832, BC051707, DA231935
      Consensus CDS
      CCDS14501.1
      UniProtKB/Swiss-Prot
      Q96D09
      UniProtKB/TrEMBL
      B3KW05
      Related
      ENSP00000437394.1, ENST00000535209.6
      Conserved Domains (2) summary
      pfam04826
      Location:593837
      Arm_2; Armadillo-like
      cl26386
      Location:1163
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    4. NM_001184876.3NP_001171805.1  G-protein coupled receptor-associated sorting protein 2

      See identical proteins and their annotated locations for NP_001171805.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AK123832, BC051707, DA776293
      Consensus CDS
      CCDS14501.1
      UniProtKB/Swiss-Prot
      Q96D09
      UniProtKB/TrEMBL
      B3KW05
      Related
      ENSP00000508139.1, ENST00000486814.2
      Conserved Domains (2) summary
      pfam04826
      Location:593837
      Arm_2; Armadillo-like
      cl26386
      Location:1163
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    5. NM_138437.6NP_612446.1  G-protein coupled receptor-associated sorting protein 2

      See identical proteins and their annotated locations for NP_612446.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AK123832, BC051707
      Consensus CDS
      CCDS14501.1
      UniProtKB/Swiss-Prot
      Q96D09
      UniProtKB/TrEMBL
      B3KW05
      Related
      ENSP00000339057.3, ENST00000332262.10
      Conserved Domains (2) summary
      pfam04826
      Location:593837
      Arm_2; Armadillo-like
      cl26386
      Location:1163
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      102712448..102717733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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