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    RNF157 ring finger protein 157 [ Homo sapiens (human) ]

    Gene ID: 114804, updated on 11-Jun-2021

    Summary

    Official Symbol
    RNF157provided by HGNC
    Official Full Name
    ring finger protein 157provided by HGNC
    Primary source
    HGNC:HGNC:29402
    See related
    Ensembl:ENSG00000141576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in brain (RPKM 16.0), testis (RPKM 13.4) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RNF157 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (76142456..76240493, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74138555..74236574, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928447 Neighboring gene RNF157 antisense RNA 1 Neighboring gene forkhead box J1 Neighboring gene ATP synthase membrane subunit g pseudogene 6 Neighboring gene activating transcription factor 4 pseudogene 3 Neighboring gene uncharacterized LOC105371896 Neighboring gene uncharacterized LOC107985019

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of dendrite extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin ligase RNF157
    Names
    RING-type E3 ubiquitin transferase RNF157
    NP_001317430.1
    NP_443148.1
    XP_005257064.1
    XP_011522575.1
    XP_016879606.1
    XP_016879609.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330501.2NP_001317430.1  E3 ubiquitin ligase RNF157 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA609513, AB067504, AC015801, AK091467, BM310065, BM722923, BQ434552, CX872674
      Consensus CDS
      CCDS82208.1
      UniProtKB/Swiss-Prot
      Q96PX1
      Related
      ENSP00000321837.4, ENST00000319945.10
    2. NM_052916.3NP_443148.1  E3 ubiquitin ligase RNF157 isoform 1

      See identical proteins and their annotated locations for NP_443148.1

      Status: VALIDATED

      Source sequence(s)
      AA932192, AB067504, AC015801, AK055949, AK091467, BI857136, BM474134, CX872674
      Consensus CDS
      CCDS32740.1
      UniProtKB/Swiss-Prot
      Q96PX1
      Related
      ENSP00000269391.4, ENST00000269391.11
      Conserved Domains (1) summary
      pfam13920
      Location:276318
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      76142456..76240493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257007.4XP_005257064.1  E3 ubiquitin ligase RNF157 isoform X2

      Conserved Domains (1) summary
      pfam13920
      Location:276318
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    2. XM_017024117.2XP_016879606.1  E3 ubiquitin ligase RNF157 isoform X1

    3. XM_017024120.2XP_016879609.1  E3 ubiquitin ligase RNF157 isoform X3

    4. XM_011524273.3XP_011522575.1  E3 ubiquitin ligase RNF157 isoform X4

      Conserved Domains (1) summary
      pfam13920
      Location:276318
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RNA

    1. XR_001752422.1 RNA Sequence

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